Image-based multiscale modeling predicts tissue-level and network-level fiber reorganization in stretched cell-compacted collagen gels.
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From single cells to tissues: interactions between the matrix and human breast cells in real timeCell Invasion Dynamics into a Three Dimensional Extracellular Matrix Fibre NetworkMechanical strain stabilizes reconstituted collagen fibrils against enzymatic degradation by mammalian collagenase matrix metalloproteinase 8 (MMP-8)A Combined In Vitro Imaging and Multi-Scale Modeling System for Studying the Role of Cell Matrix Interactions in Cutaneous Wound HealingImaging of Scleral Collagen Deformation Using Combined Confocal Raman Microspectroscopy and Polarized Light Microscopy TechniquesStretch-induced network reconfiguration of collagen fibres in the human facet capsular ligamentMultiscale computational models of complex biological systems.Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels.Rapid quantification of pixel-wise fiber orientation data in micrographs.Computational modeling of the arterial wall based on layer-specific histological data.Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening.From single fiber to macro-level mechanics: A structural finite-element model for elastomeric fibrous biomaterials.Strain-induced collagen organization at the micro-level in fibrin-based engineered tissue constructs.Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations.Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibersCollagen-agarose co-gels as a model for collagen-matrix interaction in soft tissues subjected to indentation.Enhanced invasion of metastatic cancer cells via extracellular matrix interface.Simulated remodeling of loaded collagen networks via strain-dependent enzymatic degradation and constant-rate fiber growth.Multiscale strain analysis of tissue equivalents using a custom-designed biaxial testing device.Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture.Quantitative differentiation of normal and scarred tissues using second-harmonic generation microscopy.On integrating experimental and theoretical models to determine physical mechanisms of morphogenesisMicrostructural and mechanical differences between digested collagen-fibrin co-gels and pure collagen and fibrin gels.Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments.Mechanics and kinematics of soft tissue under indentation are determined by the degree of initial collagen fiber alignment.Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis.Fibers in the extracellular matrix enable long-range stress transmission between cellsTissue Strain Reorganizes Collagen With a Switchlike Response That Regulates Neuronal Extracellular Signal-Regulated Kinase Phosphorylation In Vitro: Implications for Ligamentous Injury and Mechanotransduction.Crack Propagation Versus Fiber Alignment in Collagen Gels: Experiments and Multiscale Simulation.Nonlinear strain stiffening is not sufficient to explain how far cells can feel on fibrous protein gelsMicroscale fiber network alignment affects macroscale failure behavior in simulated collagen tissue analogs.Biaxial tension of fibrous tissue: using finite element methods to address experimental challenges arising from boundary conditions and anisotropy.A coupled fiber-matrix model demonstrates highly inhomogeneous microstructural interactions in soft tissues under tensile load.Mechanical behavior of collagen-fibrin co-gels reflects transition from series to parallel interactions with increasing collagen content.Initial fiber alignment pattern alters extracellular matrix synthesis in fibroblast-populated fibrin gel cruciforms and correlates with predicted tension.Multiscale model predicts tissue-level failure from collagen fiber-level damageMechanics of a fiber network within a non-fibrillar matrix: model and comparison with collagen-agarose co-gelsOptical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction.A method for predicting collagen fiber realignment in non-planar tissue surfaces as applied to glenohumeral capsule during clinically relevant deformation.Let's push things forward: disruptive technologies and the mechanics of tissue assembly.
P2860
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P2860
Image-based multiscale modeling predicts tissue-level and network-level fiber reorganization in stretched cell-compacted collagen gels.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
Image-based multiscale modelin ...... cell-compacted collagen gels.
@ast
Image-based multiscale modelin ...... cell-compacted collagen gels.
@en
type
label
Image-based multiscale modelin ...... cell-compacted collagen gels.
@ast
Image-based multiscale modelin ...... cell-compacted collagen gels.
@en
prefLabel
Image-based multiscale modelin ...... cell-compacted collagen gels.
@ast
Image-based multiscale modelin ...... cell-compacted collagen gels.
@en
P2093
P2860
P356
P1476
Image-based multiscale modelin ...... cell-compacted collagen gels.
@en
P2093
Edward A Sander
Robert T Tranquillo
Victor H Barocas
P2860
P304
17675-17680
P356
10.1073/PNAS.0903716106
P407
P577
2009-10-01T00:00:00Z