Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice. - Wikidata - awgldk - TriplyDB

Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice.

Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice.

http://www.wikidata.org/entity/Q30500685

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Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4 Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells Tropomodulin capping of actin filaments in striated muscle development and physiology A novel marker for vertebrate embryonic heart, the EH-myomesin isoform Vertebrate isoforms of actin capping protein beta have distinct functions In vivo Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1 Alterations at the intercalated disk associated with the absence of muscle LIM protein Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice The Nebulin family: an actin support group The transitional junction: a new functional subcellular domain at the intercalated disc Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo Cytoplasmic nuclear transfer of the actin-capping protein tropomodulin Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy.Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis.Impaired intracellular Ca2+ dynamics in live cardiomyocytes revealed by rapid line scan confocal microscopy.Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouse Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle.Meeting Koch's postulates for calcium signaling in cardiac hypertrophy.Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.Phosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle.Erythrocyte tropomodulin isoforms with and without the N-terminal actin-binding domain Cardiac hypertrophy and failure: lessons learned from genetically engineered mice.Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes.Calcineurin and hypertrophic heart disease: novel insights and remaining questions.Cardiac-specific NRAP overexpression causes right ventricular dysfunction in mice Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice.Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortex Thin filaments elongate from their pointed ends during myofibril assembly in Drosophila indirect flight muscle.Nebulin regulates the assembly and lengths of the thin filaments in striated muscle The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes.Tropomodulins and tropomyosins: working as a team Thin filament length regulation in striated muscle sarcomeres: pointed-end dynamics go beyond a nebulin ruler.Designing heart performance by gene transfer.Quantitative Non-canonical Amino Acid Tagging (QuaNCAT) Proteomics Identifies Distinct Patterns of Protein Synthesis Rapidly Induced by Hypertrophic Agents in Cardiomyocytes, Revealing New Aspects of Metabolic Remodeling.Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development.

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P2860

Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice.

http://www.wikidata.org/entity/Q30500685

description

1998 nî lūn-bûn

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1998 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1998 թվականի հունվարին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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Myofibril degeneration caused ...... rdiomyopathy in juvenile mice.

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Myofibril degeneration caused ...... rdiomyopathy in juvenile mice.

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Myofibril degeneration caused ...... rdiomyopathy in juvenile mice.

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Myofibril degeneration caused ...... rdiomyopathy in juvenile mice.

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Myofibril degeneration caused ...... rdiomyopathy in juvenile mice.

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P2093

M A Sussman

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N Cambon

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R Klevitsky

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T E Hewett

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P2860

Tropomodulin caps the pointed ends of actin filaments

Molecular and physiological effects of overexpressing striated muscle beta-tropomyosin in the adult murine heart

Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood

A mouse model of familial hypertrophic cardiomyopathy

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

Cellular versus myocardial basis for the contractile dysfunction of hypertrophied myocardium.

Isolation and characterization of the mouse cardiac myosin heavy chain genes.

MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure.

Right ventricular dysplasia: a report of 24 adult cases.

Ultrastructural features of degenerated cardiac muscle cells in patients with cardiac hypertrophy.

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