The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement. - Wikidata - awgldk - TriplyDB

The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.

The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.

http://www.wikidata.org/entity/Q30503547

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Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks The germinal center antibody response in health and disease Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential Regulation of germinal center B-cell differentiation S1PR2 links germinal center confinement and growth regulation Molecular programming of B cell memory Sphingolipid signaling in metabolic disorders Lysophospholipid receptors in drug discovery.Exit Strategies: S1P Signaling and T Cell Migration Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers.Novel insights into G protein and G protein-coupled receptor signaling in cancer Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility.Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient.An update on the biology of sphingosine 1-phosphate receptors.Lysophospholipid receptor nomenclature review: IUPHAR Review 8.The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma.Sphingolipid metabolites in inflammatory disease.Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.Dynamics of B cells in germinal centres.Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy.Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13 Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin's lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells.Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers Visualizing S1P-directed cellular egress by intravital imaging The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination A map of the distribution of sphingosine 1-phosphate in the spleen Phospholipids: "greasing the wheels" of humoral immunity Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory CXCR4 promotes B cell egress from Peyer's patches.Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing Endothelial Plasmalemma Vesicle-Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells.Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma.

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The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.

http://www.wikidata.org/entity/Q30503547

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Nature Immunology

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Bryan Cho

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Christopher D C Allen

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Daniel Palmer

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Jason G Cyster

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Jesse A Green

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Kazuhiro Suzuki

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L David Willison

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Richard L Proia

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Shaun R Coughlin

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Timothy H Schmidt

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Essential role for Galpha13 in endothelial cells during embryonic development

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor

S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

EBI2 mediates B cell segregation between the outer and centre follicle

Molecular mechanisms of mTOR-mediated translational control

Germinal centers

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

Sphingosine-1-phosphate: an enigmatic signalling lipid

Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils

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21642988

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