Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model
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ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humansReduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk.Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.Characterization of in vitro glucuronidation clearance of a range of drugs in human kidney microsomes: comparison with liver and intestinal glucuronidation and impact of albumin.In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383Intracellular drug bioavailability: a new predictor of system dependent drug disposition.Drug-drug interaction studies: regulatory guidance and an industry perspectiveSandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporineIntracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.Compartmental models for apical efflux by P-glycoprotein: part 2--a theoretical study on transporter kinetic parameters.Compartmental models for apical efflux by P-glycoprotein--part 1: evaluation of model complexity.Species differences in drug transporters and implications for translating preclinical findings to humans.Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters.Permeability comparison between hepatocyte and low efflux MDCKII cell monolayer.Intracellular Unbound Atorvastatin Concentrations in the Presence of Metabolism and Transport.Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat.Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytesExperimental and mathematical analysis of in vitro Pitavastatin hepatic uptake across species.Online monitoring of hepatic rat metabolism by coupling a liver biochip and a mass spectrometer.Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach.
P2860
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P2860
Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Simultaneous assessment of upt ...... omprehensive mechanistic model
@ast
Simultaneous assessment of upt ...... omprehensive mechanistic model
@en
type
label
Simultaneous assessment of upt ...... omprehensive mechanistic model
@ast
Simultaneous assessment of upt ...... omprehensive mechanistic model
@en
prefLabel
Simultaneous assessment of upt ...... omprehensive mechanistic model
@ast
Simultaneous assessment of upt ...... omprehensive mechanistic model
@en
P2093
P2860
P356
P1476
Simultaneous assessment of upt ...... omprehensive mechanistic model
@en
P2093
J Brian Houston
Karelle Ménochet
Kathryn E Kenworthy
P2860
P356
10.1124/JPET.111.187112
P407
P577
2011-12-21T00:00:00Z