High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction
about
Bernard-Soulier syndromeF-actin clustering and cell dysmotility induced by the pathological W148R missense mutation of filamin B at the actin-binding domainProteasome proteolysis supports stimulated platelet function and thrombosisGenetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis.Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.New insights into the versatile roles of platelet FlnA.Inherited thrombocytopenias: an approach to diagnosis and management.A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.Filamins in mechanosensing and signaling.Suppressive effect of CORM-2 on LPS-induced platelet activation by glycoprotein mediated HS1 phosphorylation interferenceThe dual role of filamin A in cancer: can't live with (too much of) it, can't live without it.GPIbα regulates platelet size by controlling the subcellular localization of filaminDynamic force sensing of filamin revealed in single-molecule experiments.Suppressive effect of exogenous carbon monoxide on endotoxin-stimulated platelet over-activation via the glycoprotein-mediated PI3K-Akt-GSK3β pathwayPlatelet clearance via shear-induced unfolding of a membrane mechanoreceptor.14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.Membrane skeleton orchestrates the platelet glycoprotein (GP) Ib-IX complex clustering and signaling.Advances in our understanding of the molecular basis of disorders of platelet function.Novel roles of cAMP/cGMP-dependent signaling in platelets.Platelets: key players in vascular inflammation.Of von Willebrand factor and platelets.Aging of platelets stored for transfusion.New Concepts and Mechanisms of Platelet Activation Signaling.Platelet GPIb: sensing force and responding.GPVI modulation during platelet activation and storage: its expression levels and ectodomain shedding compared to markers of platelet storage lesion.
P2860
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P2860
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
High shear-dependent loss of m ...... the GPIbα-filamin interaction
@ast
High shear-dependent loss of m ...... the GPIbα-filamin interaction
@en
type
label
High shear-dependent loss of m ...... the GPIbα-filamin interaction
@ast
High shear-dependent loss of m ...... the GPIbα-filamin interaction
@en
prefLabel
High shear-dependent loss of m ...... the GPIbα-filamin interaction
@ast
High shear-dependent loss of m ...... the GPIbα-filamin interaction
@en
P2093
P2860
P1433
P1476
High shear-dependent loss of m ...... the GPIbα-filamin interaction
@en
P2093
Katrina J Ashworth
Michael C Berndt
Susan L Cranmer
Zaverio M Ruggeri
P2860
P304
P356
10.1182/BLOOD-2010-07-296194
P407
P577
2010-12-14T00:00:00Z