MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function
about
Pathogenic mechanisms in centronuclear myopathiesC-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulinMorphogenesis of the somatic musculature in Drosophila melanogasterThe Formin Diaphanous Regulates Myoblast Fusion through Actin Polymerization and Arp2/3 RegulationLinker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts.A model of muscle atrophy based on live microscopy of muscle remodelling in Drosophila metamorphosis.Nuclear migration events throughout developmentMuscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organizationMicrotubules that form the stationary lattice of muscle fibers are dynamic and nucleated at Golgi elements.Altered nuclear dynamics in MDX myofibers.Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3Organelle positioning in muscles requires cooperation between two KASH proteins and microtubules.Opposing microtubule motors drive robust nuclear dynamics in developing muscle cells.The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance.Translocating myonuclei have distinct leading and lagging edges that require kinesin and dyneinEnsconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells.KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.Nucleus-dependent sarcomere assembly is mediated by the LINC complex.The WASP-Arp2/3 complex signal cascade is involved in actin-dependent sperm nuclei migration during double fertilization in tobacco and maizeMicrotubule motors involved in nuclear movement during skeletal muscle differentiationDistinct molecular cues ensure a robust microtubule-dependent nuclear positioning in the Drosophila oocyteMechanism and regulation of kinesin-5, an essential motor for the mitotic spindle.Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscleRegulation of microtubule-based transport by MAP4Identification of genomic regions associated with feed efficiency in Nelore cattleWhole-genome analysis of muscle founder cells implicates the chromatin regulator Sin3A in muscle identityN-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy.Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.Muscle cell fate choice requires the T-box transcription factor midline in DrosophilaSyd/JIP3 and JNK signaling are required for myonuclear positioning and muscle function.Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia.Nesprin provides elastic properties to muscle nuclei by cooperating with spectraplakin and EB1.Fluctuation Analysis of Centrosomes Reveals a Cortical Function of Kinesin-1.Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody.Muscle length and myonuclear position are independently regulated by distinct Dynein pathways.toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans.Drosophila KASH-domain protein Klarsicht regulates microtubule stability and integrin receptor localization during collective cell migration.Nuclear positioning.Moving and positioning the nucleus in skeletal muscle - one step at a time
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P2860
MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function
@ast
MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function
@en
type
label
MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function
@ast
MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function
@en
prefLabel
MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function
@ast
MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function
@en
P2093
P2860
P50
P356
P1433
P1476
MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function
@en
P2093
Brian E Richardson
Eric S Folker
Mary K Baylies
Thomas Metzger
P2860
P2888
P304
P356
10.1038/NATURE10914
P407
P577
2012-03-18T00:00:00Z
P5875
P6179
1018911694