Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
about
Medical treatment for gastro-entero-pancreatic neuroendocrine tumoursConcerning immune synapses: a spatiotemporal timelineProgrammed cell death protein-1/programmed cell death ligand-1 pathway inhibition and predictive biomarkers: understanding transforming growth factor-beta roleHuman Cancer Immunotherapy with PD-1/PD-L1 BlockadeMolecular and cellular insights into T cell exhaustionUnderstanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpointsThe programmed death-1 immune-suppressive pathway: barrier to antitumor immunityOvercoming T cell exhaustion in infection and cancerMolecular mechanisms of T cell co-stimulation and co-inhibitionRegulation of Neuroinflammation through Programed Death-1/Programed Death Ligand Signaling in Neurological DisordersThe immunological synapse: the gateway to the HIV reservoirImpaired T-Cell Function in B-Cell Lymphoma: A Direct Consequence of Events at the Immunological Synapse?New immunotherapies targeting the PD-1 pathwayNew antibody approaches to lymphoma therapyTuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues.Structure and Interactions of the Human Programmed Cell Death 1 ReceptorThe PD1:PD-L1/2 Pathway from Discovery to Clinical ImplementationDiacylglycerol Kinases (DGKs): Novel Targets for Improving T Cell Activity in CancerRadiation-induced immune responses: mechanisms and therapeutic perspectivesT cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatasesA Key Role for Inhibins in Dendritic Cell Maturation and Function.PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responsesProgrammed cell death-1 is expressed in large retinal ganglion cells and is upregulated after optic nerve crush.Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathwayFine-tuning T cell receptor signaling to control T cell developmentBiochemical signaling of PD-1 on T cells and its functional implicationsProgrammed cell death 1 (PD-1) regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes.Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infectionOX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.A quantitative assessment of costimulation and phosphatase activity on microclusters in early T cell signaling.PD-1/SHP-2 inhibits Tc1/Th1 phenotypic responses and the activation of T cells in the tumor microenvironmentBlocking immunosuppressive checkpoints for glioma therapy: the more the Merrier!Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated CancersInducible expression of B7-H1 (PD-L1) and its selective role in tumor site immune modulation.ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.Inhibitory Receptors Beyond T Cell Exhaustion.T cell activation is reduced by the catalytically inactive form of protein tyrosine phosphatase SHP-2Charting Immune Signaling Proteomes En Route to New Therapeutic Strategies.
P2860
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P2860
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Programmed cell death 1 forms ...... y recruiting phosphatase SHP2.
@ast
Programmed cell death 1 forms ...... y recruiting phosphatase SHP2.
@en
type
label
Programmed cell death 1 forms ...... y recruiting phosphatase SHP2.
@ast
Programmed cell death 1 forms ...... y recruiting phosphatase SHP2.
@en
prefLabel
Programmed cell death 1 forms ...... y recruiting phosphatase SHP2.
@ast
Programmed cell death 1 forms ...... y recruiting phosphatase SHP2.
@en
P2093
P2860
P356
P1476
Programmed cell death 1 forms ...... y recruiting phosphatase SHP2.
@en
P2093
Masako Takamatsu
Miyuki Azuma
Tadashi Yokosuka
Wakana Kobayashi-Imanishi
P2860
P304
P356
10.1084/JEM.20112741
P407
P577
2012-05-28T00:00:00Z