Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease - Wikidata - awgldk - TriplyDB

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

http://www.wikidata.org/entity/Q30535298

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Epigenetic Alterations in Alzheimer's Disease Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases Epigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug Response Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer's Disease Epigenetics of Alzheimer's disease and frontotemporal dementia HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Epigenetic Changes in Neurodegenerative Diseases The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease The promise and perils of HDAC inhibitors in neurodegeneration Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington's disease.Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition.Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.Acetylation: a new key to unlock tau's role in neurodegeneration The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease.Epigenetic regulation of estrogen-dependent memory.Epigenetic memory: the Lamarckian brain K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection.Tubulin acetylation: responsible enzymes, biological functions and human diseases.Epigenetic control of learning and memory in Drosophila by Tip60 HAT action.Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers New HDAC6-mediated deacetylation sites of tubulin in the mouse brain identified by quantitative mass spectrometry Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors--What Some May Have Forgotten or Would Rather Forget?Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by a non-neutral HDAC6 variant Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6 Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance.Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability.Back to the tubule: microtubule dynamics in Parkinson's disease.Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases.Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport.Regulation of autophagy and mitophagy by nutrient availability and acetylation.Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors.Generating new neurons to circumvent your fears: the role of IGF signaling.Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia.Epigenetic drug discovery for Alzheimer's disease.Histone-acetylation: a link between Alzheimer's disease and post-traumatic stress disorder?Coenzyme A, more than 'just' a metabolic cofactor.

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P2860

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

http://www.wikidata.org/entity/Q30535298

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2012 nî lūn-bûn

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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

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Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

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type

label

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

@ast

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

@en

prefLabel

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

@ast

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

@en

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EMBO Molecular Medicine

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Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

@en

P2093

André Fischer

http://www.w3.org/2001/XMLSchema#string

Farahnaz Sananbenesi

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Oliver M Schlüter

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Susanne Burkhardt

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P2860

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6

HDAC6 is a microtubule-associated deacetylase

Histone deacetylase 6 interacts with the microtubule-associated protein tau

Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin

HDAC2 negatively regulates memory formation and synaptic plasticity.

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

HDAC6 regulates mitochondrial transport in hippocampal neurons

Microtubule acetylation promotes kinesin-1 binding and transport.

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

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52-63

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scholarly article

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10.1002/EMMM.201201923

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1

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5

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Nambirajan Govindarajan

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2012-11-26T00:00:00Z

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233774792

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23184605

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Alzheimer's disease

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3569653

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