Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes - Wikidata - awgldk - TriplyDB

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

http://www.wikidata.org/entity/Q30536567

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Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's Disease Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin.Delayed emergence of subdiffraction-sized mutant huntingtin fibrils following inclusion body formation.Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy.Targets for future clinical trials in Huntington's disease: what's in the pipeline?Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.TRiC's tricks inhibit huntingtin aggregation.TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease scyllo-Inositol promotes robust mutant Huntingtin protein degradation.The chaperonin CCT inhibits assembly of α-synuclein amyloid fibrils by a specific, conformation-dependent interaction.Barcoding heat shock proteins to human diseases: looking beyond the heat shock response Huntington's disease: Molecular basis of pathology and status of current therapeutic approaches Vaccinia-Related Kinase 2 Controls the Stability of the Eukaryotic Chaperonin TRiC/CCT by Inhibiting the Deubiquitinating Enzyme USP25 Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice.Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.CCT complex restricts neuropathogenic protein aggregation via autophagy.An information theoretic framework reveals a tunable allosteric network in group II chaperonins.Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis.Fluorescence nanoscopy in cell biology.Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid.Huntington disease

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Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

http://www.wikidata.org/entity/Q30536567

description

2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Exogenous delivery of chaperon ...... Huntingtin cellular phenotypes

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Exogenous delivery of chaperon ...... Huntingtin cellular phenotypes

@en

type

label

Exogenous delivery of chaperon ...... Huntingtin cellular phenotypes

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Exogenous delivery of chaperon ...... Huntingtin cellular phenotypes

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prefLabel

Exogenous delivery of chaperon ...... Huntingtin cellular phenotypes

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Exogenous delivery of chaperon ...... Huntingtin cellular phenotypes

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PNAS.1222663110

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Exogenous delivery of chaperon ...... Huntingtin cellular phenotypes

@en

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Anthony Tomlinson

http://www.w3.org/2001/XMLSchema#string

Charles G Glabe

http://www.w3.org/2001/XMLSchema#string

David E Housman

http://www.w3.org/2001/XMLSchema#string

Emily M Sontag

http://www.w3.org/2001/XMLSchema#string

Leslie M Thompson

http://www.w3.org/2001/XMLSchema#string

Lukasz A Joachimiak

http://www.w3.org/2001/XMLSchema#string

Zhiqun Tan

http://www.w3.org/2001/XMLSchema#string

P2860

Metagrowth: a new resource for the building of metabolic hypotheses in microbiology

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.

Adapting proteostasis for disease intervention

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

The PredictProtein server

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.

Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.

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3077-3082

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scholarly article

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10.1073/PNAS.1222663110

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8

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110

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Steven G Potkin

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2013-01-30T00:00:00Z

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235386289

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23365139

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3581981

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