FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels
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The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic ParaplegiasSynaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X SyndromeRNA Secondary Structure Modulates FMRP's Bi-Functional Role in the MicroRNA PathwayProteostasis and RNA Binding Proteins in Synaptic Plasticity and in the Pathogenesis of Neuropsychiatric DisordersSingle-Nucleotide Mutations in FMR1 Reveal Novel Functions and Regulatory Mechanisms of the Fragile X Syndrome Protein FMRPMoving from capstones toward cornerstones: successes and challenges in applying systems biology to identify mechanisms of autism spectrum disordersDysregulation and restoration of translational homeostasis in fragile X syndromeGenetic disruption of voltage-gated calcium channels in psychiatric and neurological disordersAltered Neuronal and Circuit Excitability in Fragile X Syndrome.Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia.BK channels: multiple sensors, one activation gateChannelopathy pathogenesis in autism spectrum disordersChannelopathies and dendritic dysfunction in fragile X syndrome.Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromesMice with deficient BK channel function show impaired prepulse inhibition and spatial learning, but normal working and spatial reference memory.The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in miceTherapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and BackInsulin-Like Growth Factor 1 and Related Compounds in the Treatment of Childhood-Onset Neurodevelopmental DisordersmTOR and MAPK: from localized translation control to epilepsyIndependent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizuresA chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage responseFragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel densityNovel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticitySensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.BK Channels in the Central Nervous System.Matrix metalloproteinase-9 deletion rescues auditory evoked potential habituation deficit in a mouse model of Fragile X SyndromeGABA receptor subunit distribution and FMRP-mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism.In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndromeFrom FMRP function to potential therapies for fragile X syndrome.Habituation of reflexive and motivated behavior in mice with deficient BK channel function.Activity-dependent regulation of release probability at excitatory hippocampal synapses: a crucial role of fragile X mental retardation protein in neurotransmissionEmerging role of the KCNT1 Slack channel in intellectual disability.Modulation of the GABAergic pathway for the treatment of fragile X syndrome.N-myristoylation regulates the axonal distribution of the Fragile X-related protein FXR2PRescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule.More than a pore: ion channel signaling complexesMolecular Advances Leading to Treatment Implications for Fragile X Premutation CarriersHuman slack potassium channel mutations increase positive cooperativity between individual channelsShaping synaptic learning by the duration of postsynaptic action potential in a new STDP model.Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain.
P2860
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P2860
FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
FMRP regulates neurotransmitte ...... ntial duration via BK channels
@ast
FMRP regulates neurotransmitte ...... ntial duration via BK channels
@en
type
label
FMRP regulates neurotransmitte ...... ntial duration via BK channels
@ast
FMRP regulates neurotransmitte ...... ntial duration via BK channels
@en
prefLabel
FMRP regulates neurotransmitte ...... ntial duration via BK channels
@ast
FMRP regulates neurotransmitte ...... ntial duration via BK channels
@en
P2093
P2860
P1433
P1476
FMRP regulates neurotransmitte ...... ntial duration via BK channels
@en
P2093
Jay A Blundon
Jianmin Cui
Pan-Yue Deng
Valeria Cavalli
Vitaly A Klyachko
Yongcheol Cho
Ziv Rotman
P2860
P304
P356
10.1016/J.NEURON.2012.12.018
P407
P577
2013-02-01T00:00:00Z