Multiple quantitative trait loci modify cochlear hair cell degeneration in the Beethoven (Tmc1Bth) mouse model of progressive hearing loss DFNA36.
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Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes.Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like.A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler miceDisruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairmentSlc26a4-insufficiency causes fluctuating hearing loss and stria vascularis dysfunction.Genome-wide linkage analyses identify Hfhl1 and Hfhl3 with frequency-specific effects on the hearing spectrum of NIH Swiss miceGenetic background of Prop1(df) mutants provides remarkable protection against hypothyroidism-induced hearing impairment.High-frequency sensorineural hearing loss and its underlying genetics (Hfhl1 and Hfhl2) in NIH Swiss mice.A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J miceMutations of TMC1 cause deafness by disrupting mechanoelectrical transductionIdentities, frequencies and origins of TMC1 mutations causing DFNB7/B11 deafness in Pakistan.Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation.A modifier gene alleviates hypothyroidism-induced hearing impairment in Pou1f1dw dwarf mice.Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisitionAmino acid 572 in TMC1: hot spot or critical functional residue for dominant mutations causing hearing impairment.A QTL on Chr 5 modifies hearing loss associated with the fascin-2 variant of DBA/2J miceRNA Interference Prevents Autosomal-Dominant Hearing Loss.Hypo-functional SLC26A4 variants associated with nonsyndromic hearing loss and enlargement of the vestibular aqueduct: genotype-phenotype correlation or coincidental polymorphisms?Development of distortion product otoacoustic emissions in C57BL/6J mice.Co-deficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss.Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function
P2860
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P2860
Multiple quantitative trait loci modify cochlear hair cell degeneration in the Beethoven (Tmc1Bth) mouse model of progressive hearing loss DFNA36.
description
2006 nî lūn-bûn
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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Multiple quantitative trait lo ...... ogressive hearing loss DFNA36.
@ast
Multiple quantitative trait lo ...... ogressive hearing loss DFNA36.
@en
type
label
Multiple quantitative trait lo ...... ogressive hearing loss DFNA36.
@ast
Multiple quantitative trait lo ...... ogressive hearing loss DFNA36.
@en
prefLabel
Multiple quantitative trait lo ...... ogressive hearing loss DFNA36.
@ast
Multiple quantitative trait lo ...... ogressive hearing loss DFNA36.
@en
P2093
P2860
P50
P1433
P1476
Multiple quantitative trait lo ...... ogressive hearing loss DFNA36.
@en
P2093
Andrew J Griffith
Helmut Fuchs
Ken Kitamura
Kiyoto Kurima
Yoshihiro Noguchi
P2860
P304
P356
10.1534/GENETICS.106.057372
P407
P577
2006-04-28T00:00:00Z