Targeting the mitochondria activates two independent cell death pathways in ovarian cancer stem cells
about
Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeuticsTargeting hypoxic response for cancer therapyHarnessing the apoptotic programs in cancer stem-like cellsComponents of cancer metabolism and therapeutic interventionsRegulation of ovarian cancer stem cells or tumor-initiating cellsUsing heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancerPhase Ib study of the mitochondrial inhibitor ME-344 plus topotecan in patients with previously treated, locally advanced or metastatic small cell lung, ovarian and cervical cancers.Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1.Apoptotic death of cancer stem cells for cancer therapy.ABC transporters in CSCs membranes as a novel target for treating tumor relapse.Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit.Ovulation and extra-ovarian origin of ovarian cancerStem cell pathways contribute to clinical chemoresistance in ovarian cancerMultiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitorsOvarian cancer stem cells: are they real and why are they important?Mitochondria as therapeutic targets for cancer stem cells.Phase 1, open-label, dose escalation, safety, and pharmacokinetics study of ME-344 as a single agent in patients with refractory solid tumors.Quantitative proteomic analysis of mitochondria from human ovarian cancer cells and their paclitaxel-resistant sublinesTRA-1-60(+), SSEA-4(+), Oct4A(+), Nanog(+) Clones of Pluripotent Stem Cells in the Embryonal Carcinomas of the OvariesTLR2 enhances ovarian cancer stem cell self-renewal and promotes tumor repair and recurrenceConstitutive proteasomal degradation of TWIST-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potentialAiming to immune elimination of ovarian cancer stem cellsPhenotypic modifications in ovarian cancer stem cells following Paclitaxel treatmentPharmacology and toxicology of the novel investigational agent Cantrixil (TRX-E-002-1)Novel pharmacological modulators of autophagy and therapeutic prospects.Investigating molecular profiles of ovarian cancer: an update on cancer stem cells.Therapeutic potential of mTOR inhibitors for targeting cancer stem cells.Emerging importance of dietary phytochemicals in fight against cancer: Role in targeting cancer stem cells.Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344.Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature.Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cellsParkin and mitophagy in cancer.Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I).A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemiaLicochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction.microRNA-488 inhibits chemoresistance of ovarian cancer cells by targeting Six1 and mitochondrial function.Peroxiredoxin 3 maintains the survival of endometrial cancer stem cells by regulating oxidative stress.Adipocyte microenvironment promotes Bclxl expression and confers chemoresistance in ovarian cancer cells.Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo.Surface markers of cancer stem-like cells of ovarian cancer and their clinical relevance.
P2860
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P2860
Targeting the mitochondria activates two independent cell death pathways in ovarian cancer stem cells
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Targeting the mitochondria act ...... s in ovarian cancer stem cells
@ast
Targeting the mitochondria act ...... s in ovarian cancer stem cells
@en
type
label
Targeting the mitochondria act ...... s in ovarian cancer stem cells
@ast
Targeting the mitochondria act ...... s in ovarian cancer stem cells
@en
prefLabel
Targeting the mitochondria act ...... s in ovarian cancer stem cells
@ast
Targeting the mitochondria act ...... s in ovarian cancer stem cells
@en
P2093
P2860
P1476
Targeting the mitochondria act ...... s in ovarian cancer stem cells
@en
P2093
Ayesha B Alvero
David Brown
Jennie C Holmberg
Michele K Montagna
Vinicius Craveiro
P2860
P304
P356
10.1158/1535-7163.MCT-11-0023
P577
2011-06-15T00:00:00Z