NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. - Wikidata - awgldk - TriplyDB

NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.

NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.

http://www.wikidata.org/entity/Q30586112

about

Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628 Alpha-fetoprotein elevation in NUT midline carcinoma: a case report Mechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation.Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations Impressive Response to Dose-Dense Chemotherapy in a Patient with NUT Midline Carcinoma.The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains.The Oncoprotein BRD4-NUT Generates Aberrant Histone Modification Patterns NUT midline carcinoma mimicking a germ cell tumor: a case report Landscape of gene fusions in epithelial cancers: seq and ye shall find.NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction.Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.NUT Carcinoma of the Sublingual Gland.WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck.Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma Target and Agent Prioritization for the Children's Oncology Group-National Cancer Institute Pediatric MATCH Trial.The NSD family of protein methyltransferases in human cancer.H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development Intensive treatment and survival outcomes in NUT midline carcinoma of the head and neck.NUT midline carcinoma of the larynx: an international series and review of the literature.The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.Targeting Cancer Cells with BET Bromodomain Inhibitors.NUT carcinoma in children and adults: A multicenter retrospective study.The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies Nuclear Protein of the Testis Midline Carcinoma Masquerading as a Primary Mediastinal Seminoma Renal NUT carcinoma: a case report.Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma.NUT midline carcinoma as a primary lung tumor: a case report.Silencing of histone methyltransferase NSD3 reduces cell viability in osteosarcoma with induction of apoptosis.NUTM1 Gene Fusions Characterize a Subset of Undifferentiated Soft Tissue and Visceral Tumors.Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor.Long-term survival after relapsed NUT carcinoma of the larynx.Pediatric NUT-midline carcinoma: Therapeutic success employing a sarcoma based multimodal approach.Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease.Update on Immunohistochemistry for the Diagnosis of Lung Cancer.Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction.miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein.

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NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.

http://www.wikidata.org/entity/Q30586112

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2014 nî lūn-bûn

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年论文

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NSD3-NUT fusion oncoprotein in ...... r a novel oncogenic mechanism.

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NSD3-NUT fusion oncoprotein in ...... r a novel oncogenic mechanism.

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2159-8290.CD-14-0014

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Cancer Discovery

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NSD3-NUT fusion oncoprotein in ...... r a novel oncogenic mechanism.

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Adlai R Grayson

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Brian P Rubin

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Christopher A French

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Cristina R Antonescu

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Erica M Walsh

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Noam Grunfeld

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Paola Dal Cin

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Rajkumar Venkatramani

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Shaila Rahman

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Simone Kühnle

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P2860

The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing

Selective inhibition of BET bromodomains

The histone variant macroH2A is an epigenetic regulator of key developmental genes

WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma

Small-molecule inhibition of BRDT for male contraception.

Regulation of chromatin by histone modifications

TopHat: discovering splice junctions with RNA-Seq

Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro

TopHat-Fusion: an algorithm for discovery of novel fusion transcripts

BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma

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928-941

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scholarly article

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10.1158/2159-8290.CD-14-0014

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8

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4

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Madeleine Lemieux

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2014-05-29T00:00:00Z

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24875858

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4125436

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