Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts.
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Recent Advances in Developing Small Molecules Targeting Nucleic AcidQuadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formationTelomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effectTargeting human telomerase for cancer therapeutics.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.An integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4.RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.Telomere and telomerase as targets for anti-cancer and regeneration therapies.Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.Small-molecule selectively recognizes human telomeric G-quadruplex DNA and regulates its conformational switch.Acridine derivatives: a patent review (2009 - 2010).A gold nanoparticle based approach for screening triplex DNA binders.Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifsModelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs.Antitumour polycyclic acridines. Palladium(0) mediated syntheses of quino[4,3,2-kl]acridines bearing peripheral substituents as potential telomere maintenance inhibitors.Putative DNA quadruplex formation within the human c-kit oncogene.DMSO increases radioiodination yield of radiopharmaceuticals.PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy.Binding modes and pathway of RHPS4 to human telomeric G-quadruplex and duplex DNA probed by all-atom molecular dynamics simulations with explicit solvent.
P2860
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P2860
Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Antitumor polycyclic acridines ...... pentacyclic acridinium salts.
@ast
Antitumor polycyclic acridines ...... pentacyclic acridinium salts.
@en
type
label
Antitumor polycyclic acridines ...... pentacyclic acridinium salts.
@ast
Antitumor polycyclic acridines ...... pentacyclic acridinium salts.
@en
prefLabel
Antitumor polycyclic acridines ...... pentacyclic acridinium salts.
@ast
Antitumor polycyclic acridines ...... pentacyclic acridinium salts.
@en
P2093
P356
P1476
Antitumor polycyclic acridines ...... pentacyclic acridinium salts.
@en
P2093
Charles A Laughton
Chetna Modi
Ian Hutchinson
Jenny C Cookson
Lloyd R Kelland
Malcolm F G Stevens
Robert A Heald
Sharon M Gowan
P304
P356
10.1021/JM011015Q
P407
P577
2002-01-01T00:00:00Z