Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
about
DNA binding specificities of Escherichia coli Cas1-Cas2 integrase drive its recruitment at the CRISPR locusCRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum.Multiplex gene regulation by CRISPR-ddCpf1Applications of CRISPR technologies in research and beyond.Evolution of RNA- and DNA-guided antivirus defense systems in prokaryotes and eukaryotes: common ancestry vs convergenceComparative genomic analysis identifies structural features of CRISPR-Cas systems in Riemerella anatipestifer.Coupling immunity and programmed cell suicide in prokaryotes: Life-or-death choices.The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacersDNA Targeting by a Minimal CRISPR RNA-Guided Cascade.Toward a genetic tool development pipeline for host-associated bacteria.Deciphering, Communicating, and Engineering the CRISPR PAM.A decade of discovery: CRISPR functions and applications.Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.Long-term genomic coevolution of host-parasite interaction in the natural environment.CRISPR-Cas12a-Assisted Recombineering in Bacteria.Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR-Cas system.High-Throughput Characterization of Cascade type I-E CRISPR Guide Efficacy Reveals Unexpected PAM Diversity and Target Sequence Preferences.Real-Time Observation of Target Search by the CRISPR Surveillance Complex Cascade.Development of a CRISPR/Cas9 genome editing toolbox for Corynebacterium glutamicum.FnCpf1: a novel and efficient genome editing tool for Saccharomyces cerevisiae.Rapid and Scalable Characterization of CRISPR Technologies Using an E. coli Cell-Free Transcription-Translation System.Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR-Cas effector complexes.Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes.A 'new lease of life': FnCpf1 possesses DNA cleavage activity for genome editing in human cells.Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips.Priming in a permissive type I-C CRISPR-Cas system reveals distinct dynamics of spacer acquisition and loss.Lactobacillus gasseri CRISPR-Cas9 characterization In Vitro reveals a flexible mode of protospacer-adjacent motif recognition.SaCas9 Requires 5'-NNGRRT-3' PAM for Sufficient Cleavage and Possesses Higher Cleavage Activity than SpCas9 or FnCpf1 in Human Cells.Determining the Specificity of Cascade Binding, Interference, and Primed Adaptation In Vivo in the Escherichia coli Type I-E CRISPR-Cas System.Cas4-Dependent Prespacer Processing Ensures High-Fidelity Programming of CRISPR Arrays.Designing Epigenome Editors: Considerations of Biochemical and Locus Specificities.A detailed cell-free transcription-translation-based assay to decipher CRISPR protospacer-adjacent motifs.CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9.Precise Excision of the CAG Tract from the Huntingtin Gene by Cas9 Nickases.Gene repression via multiplex gRNA strategy in Y. lipolytica.CRISPR-Cas adaptation in Escherichia coli requires RecBCD helicase but not nuclease activity, is independent of homologous recombination, and is antagonized by 5' ssDNA exonucleasesMinimal PAM specificity of a highly similar SpCas9 orthologMb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variantsClass 2 CRISPR/Cas: an expanding biotechnology toolbox for and beyond genome editing
P2860
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P2860
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
description
2016 nî lūn-bûn
@nan
2016 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի մարտին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
@ast
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
@en
type
label
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
@ast
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
@en
prefLabel
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
@ast
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
@en
P2093
P2860
P50
P1433
P1476
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
@en
P2093
Ahmed A Gomaa
Kenneth R Maksimchuk
Rebecca A Slotkowski
Roma N Agrawal
Ryan T Leenay
P2860
P304
P356
10.1016/J.MOLCEL.2016.02.031
P577
2016-03-30T00:00:00Z