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Hierarchical docking of databases of multiple ligand conformationsCan Invalid Bioactives Undermine Natural Product-Based Drug Discovery?Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityComprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-LactamaseComplementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain InhibitorsDevelopment of a high-throughput assay for identifying inhibitors of TBK1 and IKKεCombining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug DiscoveryGlobal mapping of pharmacological spaceProtein structure similarity as guiding principle for combinatorial library design.Compound library development guided by protein structure similarity clustering and natural product structureComputation of the physio-chemical properties and data mining of large molecular collections.Design of structural combinatorial libraries that mimic biologic motifs.High-throughput assays for promiscuous inhibitors.Combinatorial strategies for targeting protein families: application to the proteases.Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancerA Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates.Validating new tuberculosis computational models with public whole cell screening aerobic activity datasets.A physicochemical descriptor-based scoring scheme for effective and rapid filtering of kinase-like chemical space.Inhibitors of catalase-amyloid interactions protect cells from beta-amyloid-induced oxidative stress and toxicity.Saccharin: a lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods.Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.Novel approaches to developing new antibiotics for bacterial infections.Promiscuous aggregate-based inhibitors promote enzyme unfolding.Bioactivity and structure of biophenols as mediators of chronic diseases.Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts.Hydrophobicity--shake flasks, protein folding and drug discovery.Development of novel drugs from marine surface associated microorganisms.A Computational Investigation of Small-Molecule Engagement of Hot Spots at Protein-Protein Interaction Interfaces.Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011-2016).Target-independent prediction of drug synergies using only drug lipophilicity.Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors.Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures.Comprehensive evaluation of lipophilicity of biogenic amines and related compounds using different chemically bonded phases and various descriptors.A dual luciferase multiplexed high-throughput screening platform for protein-protein interactions.Methods for Virtual Screening of GPCR Targets: Approaches and Challenges.Oligo(ethylene glycol) derivatives of thioflavin T as inhibitors of protein-amyloid interactions.Bioreversible derivatives of phenol. 2. Reactivity of carbonate esters with fatty acid-like structures towards hydrolysis in aqueous solutions.Bioreversible derivatives of phenol. 1. The role of human serum albumin as related to the stability and binding properties of carbonate esters with fatty acid-like structures in aqueous solution and biological media.Mimicking Intermolecular Interactions of Tight Protein-Protein Complexes for Small-Molecule Antagonists.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Recognizing molecules with drug-like properties.
@ast
Recognizing molecules with drug-like properties.
@en
type
label
Recognizing molecules with drug-like properties.
@ast
Recognizing molecules with drug-like properties.
@en
prefLabel
Recognizing molecules with drug-like properties.
@ast
Recognizing molecules with drug-like properties.
@en
P2093
P1476
Recognizing molecules with drug-like properties.
@en
P2093
P304
P356
10.1016/S1367-5931(99)80058-1
P577
1999-08-01T00:00:00Z