Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. - Wikidata - awgldk - TriplyDB

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

http://www.wikidata.org/entity/Q30754497

about

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion.The complexity of integrins in cancer and new scopes for therapeutic targeting Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth.Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells.The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes.Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence.ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.Efficacy of ALK5 inhibition in myelofibrosis.ITGA1 is a pre-malignant biomarker that promotes therapy resistance and metastatic potential in pancreatic cancer.Exploring the Nano-Surface of Collagenous and Other Fibrotic Tissues with AFM.Dermokine contributes to epithelial-mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer.Pancreatic cancer stroma: controversies and current insights.Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.Cell signaling regulation by protein phosphorylation: a multivariate, heterogeneous, and context-dependent process.Integrin-mediated mechanotransduction.Force-dependent breaching of the basement membrane.Focal adhesion kinase signaling in unexpected places.Pharmacotherapeutic Management of Pancreatic Ductal Adenocarcinoma: Current and Emerging Concepts.Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis.Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy.Stiffness of pancreatic cancer cells is associated with increased invasive potential.Gastric adenocarcinoma.Emerging roles of mechanical forces in chromatin regulation.Developing Cures: Targeting Ontogenesis in Cancer.Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells.Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice EMT and Treatment Resistance in Pancreatic Cancer.Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses.Splice variants as novel targets in pancreatic ductal adenocarcinoma.Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis.Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells.α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site.KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis.Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.Transient targeting of the pancreatic cancer stroma as a 'fine-tuned' anti-tumor and anti-metastatic therapy.Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma.The fibrotic tumor stroma.

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P2860

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

http://www.wikidata.org/entity/Q30754497

description

2016 nî lūn-bûn

@nan

2016 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2016 թվականի ապրիլին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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name

Genotype tunes pancreatic duct ...... ibrosis and tumor progression.

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Genotype tunes pancreatic duct ...... ibrosis and tumor progression.

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type

label

Genotype tunes pancreatic duct ...... ibrosis and tumor progression.

@ast

Genotype tunes pancreatic duct ...... ibrosis and tumor progression.

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prefLabel

Genotype tunes pancreatic duct ...... ibrosis and tumor progression.

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Genotype tunes pancreatic duct ...... ibrosis and tumor progression.

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Nature Medicine

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Genotype tunes pancreatic duct ...... ibrosis and tumor progression.

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Alex S Barrett

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David D Schlaepfer

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Eric A Collisson

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Kirk Hansen

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Laura D Wood

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P2860

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench

DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.

SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer.

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

Tensional homeostasis and the malignant phenotype

Comprehensive molecular profiling of lung adenocarcinoma.

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

Role of YAP/TAZ in mechanotransduction

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10.1038/NM.4082

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Harold L. Moses

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Valerie M Weaver

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