Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.

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http://www.wikidata.org/entity/Q30823595
The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration?The Dual Role of Microglia in ALS: Mechanisms and Therapeutic Approaches.Environment-transformable sequence-structure relationship: a general mechanism for proteotoxicity.Profilin Directly Promotes Microtubule Growth through Residues Mutated in Amyotrophic Lateral Sclerosis.The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease.Amyotrophic lateral sclerosis-related mutant superoxide dismutase 1 aggregates inhibit 14-3-3-mediated cell survival by sequestration into the JUNQ compartment.Incorporating upper motor neuron health in ALS drug discovery.A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants.Autophagy as a common pathway in amyotrophic lateral sclerosis.The ALS-inducing factors, TDP43 and SOD1, directly affect and sensitize sensory neurons to stressRNA-Seq Analysis of Spinal Cord Tissues from hPFN1 Transgenic Mouse Model of ALS at Pre-symptomatic and End-Stages of Disease
P2860

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.

Item
http://www.wikidata.org/entity/Q30823595
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2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Mutant PFN1 causes ALS phenoty ...... in mice by a gain of toxicity.
@ast
Mutant PFN1 causes ALS phenoty ...... in mice by a gain of toxicity.
@en
type
label
Mutant PFN1 causes ALS phenoty ...... in mice by a gain of toxicity.
@ast
Mutant PFN1 causes ALS phenoty ...... in mice by a gain of toxicity.
@en
prefLabel
Mutant PFN1 causes ALS phenoty ...... in mice by a gain of toxicity.
@ast
Mutant PFN1 causes ALS phenoty ...... in mice by a gain of toxicity.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Mutant PFN1 causes ALS phenoty ...... in mice by a gain of toxicity.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932