about
Privileged scaffolds for library design and drug discoveryChemistry, biology, and medicinal potential of narciclasine and its congenersExpanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsModern natural products drug discovery and its relevance to biodiversity conservationParallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization.Exploration of Scaffolds from Natural Products with Antiplasmodial Activities, Currently Registered Antimalarial Drugs and Public Malarial Screen Data.Natural products as templates for bioactive compound libraries: synthesis of biaryl derivatives of (+/-)-vasicine.Natural products as templates for bioactive compound libraries: part 2. Novel modifications of vasicine (peganine) core via efficient and regioselective generation of 3-lithiodeoxyvasicine and its stereoselective addition to aliphatic ketones sectioStructural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones.Naturally diverse: highlights in versatile synthetic methods enabling target- and diversity-oriented synthesis.Probing chemical space with alkaloid-inspired libraries.Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agentsSolid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like libraryEvaluation of antimicrobial and cytotoxic activities of plant extracts from southern Minas Gerais cerrado.Nitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural productsSynthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.Molecular scaffold analysis of natural products databases in the public domain.Drug-likeness analysis of traditional Chinese medicines: 2. Characterization of scaffold architectures for drug-like compounds, non-drug-like compounds, and natural compounds from traditional Chinese medicinesEmulating the logic of monoterpenoid alkaloid biogenesis to access a skeletally diverse chemical library.Syntheses of a library of molecules on the marine natural product ianthelliformisamines platform and their biological evaluation.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Carbohydrates in diversity-oriented synthesis: challenges and opportunities.Skeletal and Appendage Diversity as Design Elements in the Synthesis of a Discovery Library of Nonaromatic Polycyclic 5-Iminooxazolidin-2-ones, Hydantoins, and Acylureas.Challenges for the development of new non-toxic antifouling solutions.Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs.General allylic C-H alkylation with tertiary nucleophiles.Stereospecific cross-coupling reactions of aryl-substituted tetrahydrofurans, tetrahydropyrans, and lactones.Ethnobotanical, phytochemical and therapeutic effects of Myrtus communis L. berries seeds on gastrointestinal tract diseases: a review.Exploring β-Tubulin Inhibitors from Plant Origin using Computational Approach.Strategies to diversify natural products for drug discovery.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Libraries from natural product-like scaffolds.
@ast
Libraries from natural product-like scaffolds.
@en
type
label
Libraries from natural product-like scaffolds.
@ast
Libraries from natural product-like scaffolds.
@en
prefLabel
Libraries from natural product-like scaffolds.
@ast
Libraries from natural product-like scaffolds.
@en
P1476
Libraries from natural product-like scaffolds.
@en
P2093
Armen M Boldi
P304
P356
10.1016/J.CBPA.2004.04.010
P577
2004-06-01T00:00:00Z