Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
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Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissueConformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activitiesEuphohelioscopin A is a PKC activator capable of inducing macrophage differentiation.Rational design of drugs that induce human immunodeficiency virus replication.Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis.Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains.Wealth of opportunity - the C1 domain as a target for drug development.Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase CConformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteinsPolar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agentsVariability in content of the anti-AIDS drug candidate prostratin in Samoan populations of Homalanthus nutans.Peptide-based ligand screening and functional analysis of protein kinase C.C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities.Development of diacyltetrol lipids as activators for the C1 domain of protein kinase C.A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions.Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.The C1 domain of Vav3, a novel potential therapeutic target.Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP.Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C.Characterization of AJH-836, a DAG-lactone with selectivity for novel PKC isozymes.Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C.
P2860
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P2860
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
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2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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name
Conformationally constrained a ...... affinity to protein kinase C?
@ast
Conformationally constrained a ...... affinity to protein kinase C?
@en
type
label
Conformationally constrained a ...... affinity to protein kinase C?
@ast
Conformationally constrained a ...... affinity to protein kinase C?
@en
prefLabel
Conformationally constrained a ...... affinity to protein kinase C?
@ast
Conformationally constrained a ...... affinity to protein kinase C?
@en
P2093
P356
P1476
Conformationally constrained a ...... affinity to protein kinase C?
@en
P2093
Benzaria S
Bhattacharyya DK
Bienfait B
Blumberg PM
Marquez VE
P304
P356
10.1021/JM9904607
P407
P577
2000-03-01T00:00:00Z