The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families.
about
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrationsThe dispanins: a novel gene family of ancient origin that contains 14 human membersFunctional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of ViridiplantaeThe cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporterCrystal structure of a eukaryotic phosphate transporterHeptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapyThe solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian speciesQuantifying the relative contributions of different solute carriers to aggregate substrate transportNew genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acidAmino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2)Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neuronsHistological analysis of SLC38A6 (SNAT6) expression in mouse brain shows selective expression in excitatory neurons with high expression in the synapsesGlutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters: evolution and tissue expression.Molecular modeling and ligand docking for solute carrier (SLC) transportersComparison of human solute carriersThe cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy HomeostasisThe Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake.Putative Membrane-Bound Transporters MFSD14A and MFSD14B Are Neuronal and Affected by Nutrient Availability.B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brainVesicular and conductive mechanisms of nucleotide release.The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat dietRole of membrane transporters in the safety profile of drugs.Current understanding of hepatic and intestinal OATP-mediated drug-drug interactions.Role of transporters in drug interactions.Polyamines and membrane transporters.Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?Structure and function of nucleotide sugar transporters: Current progress.Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism.SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway.The gene expression of numerous SLC transporters is altered in the immortalized hypothalamic cell line N25/2 following amino acid starvation.Activation of lysosomal P2X4 by ATP transported into lysosomes via VNUT/SLC17A9 using V-ATPase generated voltage gradient as the driving force.Therapeutic Potential and Utility of Elacridar with Respect to P-glycoprotein Inhibition: An Insight from the Published In Vitro, Preclinical and Clinical Studies.Characterization of 22 Antituberculosis Drugs for Inhibitory Interaction Potential on Organic Anionic Transporter Polypeptide (OATP)-Mediated Uptake.Di- and tripeptide transport in vertebrates: the contribution of teleost fish models.Differential expression of select members of the SLC family of genes and regulation of expression by microRNAs in the chicken oviduct.Inhibitory Interaction Potential of 22 Antituberculosis Drugs on Organic Anion and Cation Transporters of the SLC22A Family.Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression.Genomic and expression analysis of a solute carrier protein (CcSLC25a5) gene from Cyprinus carpio Linnaeus.Evaluation of para-Aminosalicylic Acid as a Substrate of Multiple Solute Carrier Uptake Transporters and Possible Drug Interactions with Nonsteroidal Anti-inflammatory Drugs In Vitro.
P2860
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P2860
The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families.
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The solute carrier (SLC) compl ...... n reveals four major families.
@ast
The solute carrier (SLC) compl ...... n reveals four major families.
@en
type
label
The solute carrier (SLC) compl ...... n reveals four major families.
@ast
The solute carrier (SLC) compl ...... n reveals four major families.
@en
prefLabel
The solute carrier (SLC) compl ...... n reveals four major families.
@ast
The solute carrier (SLC) compl ...... n reveals four major families.
@en
P2093
P2860
P1433
P1476
The solute carrier (SLC) compl ...... on reveals four major families
@en
P2093
Helgi B Schiöth
Maria G A Hägglund
Olga Stephansson
P2860
P304
P356
10.1016/J.FEBSLET.2008.10.016
P407
P577
2008-10-21T00:00:00Z