about
ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium TriadElucidating the modes of action for bioactive compounds in a cell-specific manner by large-scale chemically-induced transcriptomicsRepresenting high throughput expression profiles via perturbation barcodes reveals compound targetsRelating Chemical Structure to Cellular Response: An Integrative Analysis of Gene Expression, Bioactivity, and Structural Data Across 11,000 Compounds.Transcriptional Characterization of Compounds: Lessons Learned from the Public LINCS Data.Big-data-based edge biomarkers: study on dynamical drug sensitivity and resistance in individuals.Detection and removal of spatial bias in multiwell assays.Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discoveryNetwork pharmacology applications to map the unexplored target space and therapeutic potential of natural products.l1kdeconv: an R package for peak calling analysis with LINCS L1000 data.PLATE-Seq for genome-wide regulatory network analysis of high-throughput screens.Next-generation phenotypic screening.CF airway smooth muscle transcriptome reveals a role for PYK2.VB-MK-LMF: fusion of drugs, targets and interactions using variational Bayesian multiple kernel logistic matrix factorization.Identification of candidate drugs using tensor-decomposition-based unsupervised feature extraction in integrated analysis of gene expression between diseases and DrugMatrix datasets.A linear programming computational framework integrates phosphor-proteomics and prior knowledge to predict drug efficacy.Multi-target drug repositioning by bipartite block-wise sparse multi-task learning.Harnessing the biological complexity of Big Data from LINCS gene expression signatures
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Compound signature detection on LINCS L1000 big data.
@ast
Compound signature detection on LINCS L1000 big data.
@en
type
label
Compound signature detection on LINCS L1000 big data.
@ast
Compound signature detection on LINCS L1000 big data.
@en
prefLabel
Compound signature detection on LINCS L1000 big data.
@ast
Compound signature detection on LINCS L1000 big data.
@en
P2093
P2860
P356
P1433
P1476
Compound signature detection on LINCS L1000 big data.
@en
P2093
P2860
P304
P356
10.1039/C4MB00677A
P50
P577
2015-01-22T00:00:00Z