Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src. - Wikidata - awgldk - TriplyDB

Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src.

Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src.

http://www.wikidata.org/entity/Q30931456

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Spatial regulation of epidermal growth factor receptor signaling by endocytosis EGF receptor trafficking: consequences for signaling and cancer Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy A comprehensive, multi-scale dynamical model of ErbB receptor signal transduction in human mammary epithelial cells Marked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibition AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics.EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization Protein mislocalization: mechanisms, functions and clinical applications in cancer.Lung injury and cancer: Mechanistic insights into ceramide and EGFR signaling under cigarette smoke.Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells.A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor.Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation.Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab.Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells Cigarette smoke induces aberrant EGF receptor activation that mediates lung cancer development and resistance to tyrosine kinase inhibitors.Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells.Antibiotic monensin synergizes with EGFR inhibitors and oxaliplatin to suppress the proliferation of human ovarian cancer cells.Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling.Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer.Protein trafficking in colorectal carcinogenesis-targeting and bypassing resistance to currently applied treatments.EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling.USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor.Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors."The Lower Threshold" phenomenon in tumor cells toward endogenous digitalis-like compounds: Responsible for tumorigenesis?The ShcD phosphotyrosine adaptor subverts canonical EGF receptor trafficking.Systematic, network-based characterization of therapeutic target inhibitors.Sortilin limits EGFR signaling by promoting its internalization in lung cancer.Increased EHD1 in non-small cell lung cancer predicts poor survival.Intravesicular epidermal growth factor receptor subject to retrograde trafficking drives epidermal growth factor-dependent migration.

P2860

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P2860

Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src.

http://www.wikidata.org/entity/Q30931456

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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Aberrant trafficking of NSCLC- ...... promotes interaction with Src.

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Aberrant trafficking of NSCLC- ...... promotes interaction with Src.

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Aberrant trafficking of NSCLC- ...... promotes interaction with Src.

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Aberrant trafficking of NSCLC- ...... promotes interaction with Src.

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BMC Cell Biology

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Aberrant trafficking of NSCLC- ...... promotes interaction with Src.

@en

P2093

Byung Min Chung

http://www.w3.org/2001/XMLSchema#string

Chun Tu

http://www.w3.org/2001/XMLSchema#string

Hamid Band

http://www.w3.org/2001/XMLSchema#string

Manju George

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Robert J Clubb

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Srikumar M Raja

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Vimla Band

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P2860

Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

CAML is required for efficient EGF receptor recycling

A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation

SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

Untangling the ErbB signalling network

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

Receptor downregulation and multivesicular-body sorting

A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton

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19948031

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2790444

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