The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins.
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The Acylation Mechanism of CTX-M β-Lactamase at 0.88 Å ResolutionRe-examining the role of Lys67 in class C β-lactamase catalysisThe active site protonation states of perdeuterated Toho-1 β-lactamase determined by neutron diffraction support a role for Glu166 as the general base in acylationCrystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamaseGES-18, a New Carbapenem-Hydrolyzing GES-Type -Lactamase from Pseudomonas aeruginosa That Contains Ile80 and Ser170 ResiduesNeutron and X-ray Crystal Structures of a Perdeuterated Enzyme Inhibitor Complex Reveal the Catalytic Proton Network of the Toho-1 -Lactamase for the Acylation ReactionSupport vector regression scoring of receptor-ligand complexes for rank-ordering and virtual screening of chemical librariesA triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysisCan molecular dynamics and QM/MM solve the penicillin binding protein protonation puzzle?Molecular recognition in a diverse set of protein-ligand interactions studied with molecular dynamics simulations and end-point free energy calculations.Determination of lysine pK values using [5-13C]lysine: application to the lyase domain of DNA Pol beta.Active site detection by spatial conformity and electrostatic analysis--unravelling a proteolytic function in shrimp alkaline phosphatase.X-ray crystallographic analysis of 6-aminohexanoate-dimer hydrolase: molecular basis for the birth of a nylon oligomer-degrading enzyme.Role of Asp104 in the SHV beta-lactamase.Avibactam and inhibitor-resistant SHV β-lactamasesLigand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography.Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm.Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A β-Lactamase with a Monobactam SubstrateHydrolytic mechanism of OXA-58 enzyme, a carbapenem-hydrolyzing class D β-lactamase from Acinetobacter baumannii.Protonation states of active-site lysines of penicillin-binding protein 6 from Escherichia coli and the mechanistic implications.Molecular dynamics of class A β-lactamases-effects of substrate binding.Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases.TEM-1 backbone dynamics-insights from combined molecular dynamics and nuclear magnetic resonance.Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus.Mechanisms of proton relay and product release by Class A β-lactamase at ultrahigh resolution.Crystallographic Snapshots of Class A β-Lactamase Catalysis Reveal Structural Changes That Facilitate β-Lactam Hydrolysis.Mutations affecting the internal equilibrium of the reaction catalyzed by 6-aminohexanoate-dimer hydrolase.
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P2860
The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The importance of a critical p ...... d penicillin-binding proteins.
@ast
The importance of a critical p ...... d penicillin-binding proteins.
@en
type
label
The importance of a critical p ...... d penicillin-binding proteins.
@ast
The importance of a critical p ...... d penicillin-binding proteins.
@en
prefLabel
The importance of a critical p ...... d penicillin-binding proteins.
@ast
The importance of a critical p ...... d penicillin-binding proteins.
@en
P2093
P2860
P356
P1476
The importance of a critical p ...... d penicillin-binding proteins.
@en
P2093
Alexey Bulychev
Ann J Stemmler
Choonkeun Kim
Dasantila Golemi-Kotra
Samy O Meroueh
Sergei B Vakulenko
Shahriar Mobashery
Timothy L Stemmler
P2860
P304
34665-34673
P356
10.1074/JBC.M313143200
P407
P577
2004-05-19T00:00:00Z