Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis.
about
cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelopeA human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament proteinGenetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severityIncreased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skinPreferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosisDefining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermathThe intermediate filament network in cultured human keratinocytes is remarkably extensible and resilient.Localization of serine racemase and its role in the skinHuman keratin diseases: the increasing spectrum of disease and subtlety of the phenotype-genotype correlation.Identifying the role of specific motifs in the lens fiber cell specific intermediate filament phakosin.Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.The genetics of human skin disease.The human keratins: biology and pathology.Genetically modified mice as a tool to study inflammatory skin diseases.Disease severity correlates with position of keratin point mutations in patients with epidermolysis bullosa simplex.Dynamics of keratin assembly: exogenous type I keratin rapidly associates with type II keratin in vivo.Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin.Intermediate filaments and disease: mutations that cripple cell strength.Expression of an epidermal keratin protein in liver of transgenic mice causes structural and functional abnormalities.The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14.Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation.Functional differences between keratins of stratified and simple epithelia.Directed expression of keratin 16 to the progenitor basal cells of transgenic mouse skin delays skin maturation.Cytokeratins and dermatology.The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16.Genetically engineered mouse models for skin research: taking the next stepSkin Keratins.Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disordersA transgenic mouse model with an inducible skin blistering disease phenotype.The genetic basis of epidermolysis bullosa simplex with mottled pigmentation.Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility.Modeling cutaneous squamous carcinoma development in the mouseFormation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice.Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex.c-Met is essential for wound healing in the skin.Keith R. Porter Lecture, 1996. Of mice and men: genetic disorders of the cytoskeleton.Ichthyosis bullosa of Siemens: report of a sporadic case.The latest fashions in skin diseaseLessons from skin blistering: molecular mechanisms and unusual patterns of inheritance?Transcriptional regulation of the differentiation-linked human K4 promoter is dependent upon esophageal-specific nuclear factors.
P2860
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P2860
Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis.
description
1992 nî lūn-bûn
@nan
1992 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Transgenic mice expressing a m ...... epidermolytic hyperkeratosis.
@ast
Transgenic mice expressing a m ...... epidermolytic hyperkeratosis.
@en
type
label
Transgenic mice expressing a m ...... epidermolytic hyperkeratosis.
@ast
Transgenic mice expressing a m ...... epidermolytic hyperkeratosis.
@en
prefLabel
Transgenic mice expressing a m ...... epidermolytic hyperkeratosis.
@ast
Transgenic mice expressing a m ...... epidermolytic hyperkeratosis.
@en
P2093
P2860
P356
P1476
Transgenic mice expressing a m ...... epidermolytic hyperkeratosis.
@en
P2093
P A Coulombe
R A Esteves
P2860
P304
P356
10.1073/PNAS.89.15.6906
P407
P577
1992-08-01T00:00:00Z