about
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding FragmentsElectrophilic Fragment-Based Design of Reversible Covalent Kinase InhibitorsCrystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug designNatural-product-derived fragments for fragment-based ligand discoveryIdentification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping StrategySelectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitorsCombining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallographyp21-Activated kinase inhibitors: a patent reviewTargeting BET bromodomains for cancer treatmentApplying ligands profiling using multiple extended electron distribution based field templates and feature trees similarity searching in the discovery of new generation of urea-based antineoplastic kinase inhibitorsDiscovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.Discovery of tyrosine kinase inhibitors by docking into an inactive kinase conformation generated by molecular dynamics.Extraction and validation of substructure profiles for enriching compound libraries.Fragment-based lead discovery on G-protein-coupled receptors.Twenty years on: the impact of fragments on drug discovery.A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.Fragment informatics and computational fragment-based drug design: an overview and update.System-based drug discovery within the human kinome.Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.Facile synthesis of borofragments and their evaluation in activity-based protein profiling.Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Selectivity of kinase inhibitor fragments.
@ast
Selectivity of kinase inhibitor fragments.
@en
type
label
Selectivity of kinase inhibitor fragments.
@ast
Selectivity of kinase inhibitor fragments.
@en
prefLabel
Selectivity of kinase inhibitor fragments.
@ast
Selectivity of kinase inhibitor fragments.
@en
P2093
P356
P1476
Selectivity of kinase inhibitor fragments.
@en
P2093
Chun-wa Chung
Geoff W Mellor
John A Christopher
Murray J Brown
Paul Bamborough
P304
P356
10.1021/JM200349B
P407
P577
2011-06-23T00:00:00Z