Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors.
about
Keeping mtDNA in shape between generationsEvaluating purifying selection in the mitochondrial DNA of various mammalian speciesMitochondria and cancerClinical significance in oral cavity squamous cell carcinoma of pathogenic somatic mitochondrial mutations.A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors.Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migrationTowards imaging metabolic pathways in tissues.Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers.High-resolution genomic profiling of thyroid lesions uncovers preferential copy number gains affecting mitochondrial biogenesis loci in the oncocytic variants.A multi-parametric workflow for the prioritization of mitochondrial DNA variants of clinical interestThe opposite prognostic effect of NDUFS1 and NDUFS8 in lung cancer reflects the oncojanus role of mitochondrial complex IOncocytic lesions of the thyroid, kidney, salivary glands, adrenal cortex, and parathyroid glands.Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment.A rare, human prostate oncocyte cell originates from the prostatic carcinoma (DU145) cell line.A comprehensive characterization of rare mitochondrial DNA variants in neuroblastoma.Quantitative assessment of heteroplasmy of mitochondrial genome: perspectives in diagnostics and methodological pitfalls.Oncogenes, mitochondrial metabolism, and quality control in differentiated thyroid cancer.Global human frequencies of predicted nuclear pathogenic variants and the role played by protein hydrophobicity in pathogenicity potential.The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities.Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas.Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations.Mitochondrial mutations in human cancer: Curation of translation.Fine Time Scaling of Purifying Selection on Human Nonsynonymous mtDNA Mutations Based on the Worldwide Population Tree and Mother-Child Pairs.Mitochondrial D310 instability in Chinese lung cancer patients.Alterations of Oxidative Phosphorylation Complexes in Papillary Thyroid Carcinoma.
P2860
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P2860
Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors.
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Somatic mitochondrial DNA muta ...... tic mtDNA mutations in tumors.
@ast
Somatic mitochondrial DNA muta ...... tic mtDNA mutations in tumors.
@en
type
label
Somatic mitochondrial DNA muta ...... tic mtDNA mutations in tumors.
@ast
Somatic mitochondrial DNA muta ...... tic mtDNA mutations in tumors.
@en
prefLabel
Somatic mitochondrial DNA muta ...... tic mtDNA mutations in tumors.
@ast
Somatic mitochondrial DNA muta ...... tic mtDNA mutations in tumors.
@en
P2860
P921
P356
P1433
P1476
Somatic mitochondrial DNA muta ...... tic mtDNA mutations in tumors.
@en
P2093
Valdemar Máximo
P2860
P2888
P356
10.1186/1471-2407-12-53
P407
P5008
P577
2012-02-02T00:00:00Z
P5875
P6179
1051842448