Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase.

Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase.

Item
http://www.wikidata.org/entity/Q31087167
Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic ShuttlingPhotooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor.In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase.Novel inhibitors of anthrax edema factor.Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening.Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library.LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation.6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation.A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis.CDC25 phosphatases in cancer cells: key players? Good targets?A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway through inhibition of PTPases.Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25.G2/M accumulation in prostate cancer cell line PC-3 is induced by Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino) quinoline-5, 8-dione (DA 3003-2).Identification of the quinolinedione inhibitor binding site in Cdc25 phosphatase B through docking and molecular dynamics simulations.CDC25A-inhibitory RE derivatives bind to pocket adjacent to the catalytic site.Lewis acid-catalyzed intramolecular [3+2] cycloaddition of cyclopropane 1,1-diesters with alkynes for the synthesis of cyclopenta[c]chromene skeletons.
P2860

Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase.

Item
http://www.wikidata.org/entity/Q31087167
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Discovery and characterization ...... dual specificity phosphatase.
@ast
Discovery and characterization ...... dual specificity phosphatase.
@en
type
label
Discovery and characterization ...... dual specificity phosphatase.
@ast
Discovery and characterization ...... dual specificity phosphatase.
@en
prefLabel
Discovery and characterization ...... dual specificity phosphatase.
@ast
Discovery and characterization ...... dual specificity phosphatase.
@en
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
Discovery and characterization ...... dual specificity phosphatase.
@en
P2093
P304
P31
P356
P433
P478
P50
P577
P5875
P698