Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells. - Wikidata - awgldk - TriplyDB

Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.

Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.

http://www.wikidata.org/entity/Q31115129

about

Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells Activated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated Proteins Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen A RasGAP SH3 peptide aptamer inhibits RasGAP-Aurora interaction and induces caspase-independent tumor cell death Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I Rational design and characterization of a Rac GTPase-specific small molecule inhibitor Structure-based inhibition of protein-protein interactions.Ras history: The saga continues.RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration Determination of strongly overlapping signaling activity from microarray data.Detection of peptides, proteins, and drugs that selectively interact with protein targets.Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds.Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma.An engineered protein antagonist of K-Ras/B-Raf interaction.From laptop to benchtop to bedside: structure-based drug design on protein targets.Diversity in genetic in vivo methods for protein-protein interaction studies: from the yeast two-hybrid system to the mammalian split-luciferase system.Engineering bacterial transcription regulation to create a synthetic in vitro two-hybrid system for protein interaction assays Prospective Development of Small Molecule Targets to Oncogenic Ras Proteins In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells Drugging the undruggable RAS: Mission possible?Inhibition of Ras signaling by blocking Ras-effector interactions with cyclic peptides Identification of antituberculosis agents that target ribosomal protein interactions using a yeast two-hybrid system.Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.The p38 MAPK stress pathway as a tumor suppressor or more?Selective Raf inhibition in cancer therapy.In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors.Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007--present).Direct Modulation of Small GTPase Activity and Function.Multi-scale perturbations of protein interactomes reveal their mechanisms of regulation, robustness and insights into genotype-phenotype maps.The Mitogen-Activated Protein Kinase Pathway Facilitates Resistance to the Src Inhibitor Dasatinib in Thyroid Cancer.Direct targeting of Rab-GTPase-effector interactions.The RAS-Effector Interaction as a Drug Target.GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling.A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug.Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age.Label-free screening of drug-protein interactions by time-resolved Fourier transform infrared spectroscopic assays exemplified by Ras interactions.Investigation of the mechanism of resistance to third-generation cephalosporins by class C beta-lactamases by using chemical complementation.A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein-protein interactions identifies a novel putative Mdm2-binding site in p53.

P2860

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P2860

Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.

http://www.wikidata.org/entity/Q31115129

description

2002 nî lūn-bûn

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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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Inhibitors of Ras/Raf-1 intera ...... notypes in human cancer cells.

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Inhibitors of Ras/Raf-1 intera ...... notypes in human cancer cells.

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Inhibitors of Ras/Raf-1 intera ...... notypes in human cancer cells.

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Inhibitors of Ras/Raf-1 intera ...... notypes in human cancer cells.

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Inhibitors of Ras/Raf-1 intera ...... notypes in human cancer cells.

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Inhibitors of Ras/Raf-1 intera ...... notypes in human cancer cells.

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Proceedings of the National Academy of Sciences of the United States of America

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Inhibitors of Ras/Raf-1 intera ...... enotypes in human cancer cells

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P2093

Erica A Golemis

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Fuyuhiko Tamanoi

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Gang Zhi

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Hironori Edamatsu

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Ilya Serebriiskii

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Irina Hakimi

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Jie Zhang

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Juran Kato-Stankiewicz

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Lea Guo

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Quin-Zene Chen

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P2860

RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer

Analysis of the interaction of the novel RNA polymerase II (pol II) subunit hsRPB4 with its partner hsRPB7 and with pol II.

Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles

Mutations of the BRAF gene in human cancer

The pleitropic drug ABC transporters from Saccharomyces cerevisiae.

Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

Matrix metalloproteinases

Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner

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14398-14403

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scholarly article

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10.1073/PNAS.222222699

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22

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99

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11071592

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12391290

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137895

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