A novel compound RS-0466 reverses beta-amyloid-induced cytotoxicity through the Akt signaling pathway in vitro.

A novel compound RS-0466 reverses beta-amyloid-induced cytotoxicity through the Akt signaling pathway in vitro.

Item
http://www.wikidata.org/entity/Q31120016
Profile of gantenerumab and its potential in the treatment of Alzheimer's diseaseRS-4252 inhibits amyloid beta-induced cytotoxicity in HeLa cells.Development and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization.Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways.Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB.Identification of compound-protein interactions through the analysis of gene ontology, KEGG enrichment for proteins and molecular fragments of compounds.Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus.The Wnt signaling pathway: aging gracefully as a protectionist?The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury.Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathwaysA "FOXO" in sight: targeting Foxo proteins from conception to cancer.Targeting synaptic dysfunction in Alzheimer's disease therapy.Biological activity of sym-triazines with acetylcholine-like substitutions as multitarget modulators of Alzheimer's disease.Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species.6-Ethyl-N,N'-bis(3-hydroxyphenyl)[1,3,5]triazine-2,4-diamine (RS-0466) enhances the protective effect of brain-derived neurotrophic factor on amyloid beta-induced cytotoxicity in cortical neurones.
P2860

A novel compound RS-0466 reverses beta-amyloid-induced cytotoxicity through the Akt signaling pathway in vitro.

Item
http://www.wikidata.org/entity/Q31120016
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A novel compound RS-0466 rever ...... kt signaling pathway in vitro.
@ast
A novel compound RS-0466 rever ...... kt signaling pathway in vitro.
@en
type
label
A novel compound RS-0466 rever ...... kt signaling pathway in vitro.
@ast
A novel compound RS-0466 rever ...... kt signaling pathway in vitro.
@en
prefLabel
A novel compound RS-0466 rever ...... kt signaling pathway in vitro.
@ast
A novel compound RS-0466 rever ...... kt signaling pathway in vitro.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
A novel compound RS-0466 rever ...... kt signaling pathway in vitro.
@en
P2093
P304
P31
P356
10.1016/S0014-2999(02)02657-2
P407
P433
P478
P577
P698