A systematic method for identifying small-molecule modulators of protein-protein interactions.
about
"Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptidesCyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein InteractionsFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityMotif mediated protein-protein interactions as drug targetsIntracellular detection and evolution of site-specific proteases using a genetic selection systemDiscovery of antibacterial cyclic peptides that inhibit the ClpXP protease.Identifying small-molecule modulators of protein-protein interactions.Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal modelsSynthetic biology approaches in drug discovery and pharmaceutical biotechnology.Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.Targeting Bacillus anthracis toxicity with a genetically selected inhibitor of the PA/CMG2 protein-protein interactionPotential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein.Diversity in genetic in vivo methods for protein-protein interaction studies: from the yeast two-hybrid system to the mammalian split-luciferase system.A bidirectional fluorescent two-hybrid system for monitoring protein-protein interactions.Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway.Understanding Lipid Recognition by Protein-Mimicking Cyclic Peptides.Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanismA cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.Cyclic peptide inhibitors of the β-sliding clamp in Staphylococcus aureus.Cyclic peptides as therapeutic agents and biochemical tools.Peptides come round: using SICLOPPS libraries for early stage drug discovery.Generation of a genetically encoded, photoactivatable intein for the controlled production of cyclic peptides.Methods for the creation of cyclic Peptide libraries for use in lead discovery.Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino AcidsRibosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli.Intracellular Production of Cyclic Peptide Libraries with SICLOPPS.Ribosomal Synthesis of Thioether-Bridged Bicyclic Peptides.Ribosomal synthesis of backbone macrocyclic peptides.A promiscuous split intein with expanded protein engineering applications.The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling.Evidence for the location of the allosteric activation switch in the multisubunit phosphorylase kinase complex from mass spectrometric identification of chemically crosslinked peptides.Bioinspired strategy for the ribosomal synthesis of thioether-bridged macrocyclic peptides in bacteria.Deciphering interactions used by the influenza virus NS1 protein to silence the host antiviral sensor protein RIG-I using a bacterial reverse two-hybrid system.Directing evolution: the next revolution in drug discovery?Protein-protein interaction studies provide evidence for electron transfer from ferredoxin to lipoic acid synthase in Toxoplasma gondii.Cyclic Peptides as Inhibitors of Amyloid Fibrillation
P2860
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P2860
A systematic method for identifying small-molecule modulators of protein-protein interactions.
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A systematic method for identi ...... protein-protein interactions.
@ast
A systematic method for identi ...... protein-protein interactions.
@en
type
label
A systematic method for identi ...... protein-protein interactions.
@ast
A systematic method for identi ...... protein-protein interactions.
@en
prefLabel
A systematic method for identi ...... protein-protein interactions.
@ast
A systematic method for identi ...... protein-protein interactions.
@en
P2860
P356
P1476
A systematic method for identi ...... protein-protein interactions.
@en
P2093
Sergey N Savinov
Stephen J Benkovic
P2860
P304
15591-15596
P356
10.1073/PNAS.0406999101
P407
P577
2004-10-21T00:00:00Z