Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2. - Wikidata - awgldk - TriplyDB

Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.

Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.

http://www.wikidata.org/entity/Q31133789

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Podoplanin associates with adverse postoperative prognosis of patients with clear cell renal cell carcinoma Platelets and their role in cancer evolution and immune system Metastasis of circulating tumor cells: favorable soil or suitable biomechanics, or both?Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell-derived ADAM9.Targeting a novel domain in podoplanin for inhibiting platelet-mediated tumor metastasis Podoplanin promotes progression of malignant pleural mesothelioma by regulating motility and focus formation.Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization.Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6 Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplanin.Platelets and cancer: a casual or causal relationship: revisited.Expression of Aggrus/podoplanin in bladder cancer and its role in pulmonary metastasis.Suppression of Aggrus/podoplanin-induced platelet aggregation and pulmonary metastasis by a single-chain antibody variable region fragment Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis.PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility Use of the combination of the preoperative platelet-to-lymphocyte ratio and tumor characteristics to predict peritoneal metastasis in patients with gastric cancer.The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity.Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer.Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis.Development and characterization of anti-glycopeptide monoclonal antibodies against human podoplanin, using glycan-deficient cell lines generated by CRISPR/Cas9 and TALEN.Secrets of platelet exocytosis - what do we really know about platelet secretion mechanisms?Podoplanin--a novel marker in oral carcinogenesis.Platelets in cancer metastasis: To help the "villain" to do evil.Platelet-activating factor podoplanin: from discovery to drug development Platelets and cancer angiogenesis nexus.Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.Platelet proteomics applied to the search for novel antiplatelet therapeutic targets.Characterization of monoclonal antibody LpMab-3 recognizing sialylated glycopeptide of podoplanin.C-type lectins facilitate tumor metastasis.The influence of platelet membranes on tumour cell behaviour.Targeting Platelets for the Treatment of Cancer.Platelets contribute to growth and metastasis in hepatocellular carcinoma.Prognostic significance of preoperative neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in patients with gallbladder carcinoma.Antitumor activity of chLpMab-2, a human-mouse chimeric cancer-specific antihuman podoplanin antibody, via antibody-dependent cellular cytotoxicity.A relative increase in circulating platelets following chemoradiation predicts for poor survival of patients with glioblastoma.Clopidogrel in a combined therapy with anticancer drugs-effect on tumor growth, metastasis, and treatment toxicity: Studies in animal models.Plasma soluble podoplanin is a novel marker for the diagnosis of tumor occurrence and metastasis.C-Type Lectin-Like Receptors As Emerging Orchestrators of Sterile Inflammation Represent Potential Therapeutic Targets.

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Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.

http://www.wikidata.org/entity/Q31133789

description

2013 nî lūn-bûn

@nan

2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Platelets promote tumor growth ...... Aggrus/podoplanin and CLEC-2.

@ast

Platelets promote tumor growth ...... Aggrus/podoplanin and CLEC-2.

@en

type

label

Platelets promote tumor growth ...... Aggrus/podoplanin and CLEC-2.

@ast

Platelets promote tumor growth ...... Aggrus/podoplanin and CLEC-2.

@en

prefLabel

Platelets promote tumor growth ...... Aggrus/podoplanin and CLEC-2.

@ast

Platelets promote tumor growth ...... Aggrus/podoplanin and CLEC-2.

@en

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JOURNAL.PONE.0073609

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Platelets promote tumor growth ...... Aggrus/podoplanin and CLEC-2.

@en

P2093

Kiyohiko Hatake

http://www.w3.org/2001/XMLSchema#string

Miho Takami

http://www.w3.org/2001/XMLSchema#string

Naoya Fujita

http://www.w3.org/2001/XMLSchema#string

Satoshi Takagi

http://www.w3.org/2001/XMLSchema#string

Shigeo Sato

http://www.w3.org/2001/XMLSchema#string

Sumie Koike

http://www.w3.org/2001/XMLSchema#string

Tomoko Oh-hara

http://www.w3.org/2001/XMLSchema#string

Yuji Mishima

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors

The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis

Comprehensive genomic characterization of squamous cell lung cancers.

Podoplanin: emerging functions in development, the immune system, and cancer

The effect of low-molecular-weight heparin on cancer survival. A systematic review and meta-analysis of randomized trials

Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain

Renal cells activate the platelet receptor CLEC-2 through podoplanin

Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis.

Platelet granule secretion continuously prevents intratumor hemorrhage.

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10.1371/JOURNAL.PONE.0073609

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8

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8

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2013-08-21T00:00:00Z

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256292094

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23991201

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3749157

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