Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: synthesis, structure-activity relationship, and action mechanism studies.
about
JLK1486, a Bis 8-Hydroxyquinoline-Substituted Benzylamine, Displays Cytostatic Effects in Experimental Gliomas through MyT1 and STAT1 Activation and, to a Lesser Extent, PPARγ ActivationTumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells.Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cellsER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis.JLK1486, a N,N-[(8-hydroxyquinoline)methyl]-substituted benzylamine analogue, inhibits melanoma proliferation and induces autophagy.Preparative isolation, fast centrifugal partition chromatography purification and biological activity of cajaflavanone from Derris ferruginea stems.
P2860
Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: synthesis, structure-activity relationship, and action mechanism studies.
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Discovery of a new family of b ...... and action mechanism studies.
@ast
Discovery of a new family of b ...... and action mechanism studies.
@en
type
label
Discovery of a new family of b ...... and action mechanism studies.
@ast
Discovery of a new family of b ...... and action mechanism studies.
@en
prefLabel
Discovery of a new family of b ...... and action mechanism studies.
@ast
Discovery of a new family of b ...... and action mechanism studies.
@en
P2093
P50
P1476
Discovery of a new family of b ...... , and action mechanism studies
@en
P2093
Amandine Rolland
Christophe Béclin
Diane Allegro
Dou Q Ping
Francesca De Angelis
Geneviève Aubert
Jean-Louis Kraus
Magali Barthélémy-Requin
Thierry Cresteil
P304
P356
10.1016/J.EJMECH.2008.03.042
P577
2008-04-10T00:00:00Z