PRH represses transcription in hematopoietic cells by at least two independent mechanisms.
about
The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growthThe proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cellsAnalysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressorThe transcriptional repressor protein PRH interacts with the proteasomeCK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA bindingThe PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressorsThe zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasionThe proline rich homeodomain protein PRH/Hhex forms stable oligomers that are highly resistant to denaturationPRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling.The homeobox gene Hhex regulates the earliest stages of definitive hematopoiesis.HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin.Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming abilityA mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH.Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2aPRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate.Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex.PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin.Variations in intracellular levels of TATA binding protein can affect specific genes by different mechanisms.DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers.Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice
P2860
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P2860
PRH represses transcription in hematopoietic cells by at least two independent mechanisms.
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
PRH represses transcription in ...... st two independent mechanisms.
@ast
PRH represses transcription in ...... st two independent mechanisms.
@en
type
label
PRH represses transcription in ...... st two independent mechanisms.
@ast
PRH represses transcription in ...... st two independent mechanisms.
@en
prefLabel
PRH represses transcription in ...... st two independent mechanisms.
@ast
PRH represses transcription in ...... st two independent mechanisms.
@en
P2093
P2860
P356
P1476
PRH represses transcription in ...... st two independent mechanisms.
@en
P2093
P2860
P304
P356
10.1074/JBC.M004948200
P407
P577
2000-10-27T00:00:00Z