Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
about
Antiphospholipid antibodies: paradigm in transition.Directed engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A.Molecular defects in coagulation Factor VIII and their impact on Factor VIII function.Acquired hemophilia.Haemophilia A: effects of inhibitory antibodies on factor VIII functional interactions and approaches to prevent their action.Optimization of factor VIII replacement therapy: can structural studies help in evading antibody inhibitors?Factor VIII - novel insights into form and function.Six amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody.Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A.Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation.Identification of 31 novel mutations in the F8 gene in Spanish hemophilia A patients: structural analysis of 20 missense mutations suggests new intermolecular binding sites.Basic aspects of inhibitors to factors VIII and IX and the influence of non-genetic risk factors.Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors.Achievements, challenges and unmet needs for haemophilia patients with inhibitors: Report from a symposium in Paris, France on 20 November 2014.Engineering less immunogenic and antigenic FVIII proteins.High level expression of recombinant porcine coagulation factor VIII.Severe non-traumatic bleeding, the answer is not in the blood.False-positive results in ELISA-based anti FVIII antibody assay may occur with lupus anticoagulant and phospholipid antibodies.T cell recognition of the A2 domain of coagulation factor VIII in hemophilia patients and healthy subjects.The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex.Identification of porcine coagulation factor VIII domains responsible for high level expression via enhanced secretion.Anti-C1 domain antibodies that accelerate factor VIII clearance contribute to antibody pathogenicity in a murine hemophilia A model
P2860
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P2860
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
@ast
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
@en
type
label
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
@ast
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
@en
prefLabel
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
@ast
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
@en
P2093
P356
P1433
P1476
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.
@en
P2093
Jacquemin MG
Saint-Remy JM
P304
P356
10.1182/BLOOD.V97.1.169
P407
P577
2001-01-01T00:00:00Z