Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.
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Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagyNovel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Novel chemotherapeutic agents for the treatment of glioblastoma multiforme.Mechanisms of action of lysophospholipid analogues against trypanosomatid parasites.Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanism.AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids.Bee venom in cancer therapy.Comparative lipidomic study of urothelial cancer models: association with urothelial cancer cell invasiveness.Perifosine induces cell apoptosis in human osteosarcoma cells: new implication for osteosarcoma therapy?Perifosine sensitizes curcumin-induced anti-colorectal cancer effects by targeting multiple signaling pathways both in vivo and in vitro.Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells.The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo.Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency.Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts.ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells.On the mechanism of alkylphosphocholine (APC)-induced apoptosis in tumour cells.Effects of etherlipid analogs on cell membrane functions.Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes.Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis.c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.The membrane targeted apoptosis modulators erucylphosphocholine and erucylphosphohomocholine increase the radiation response of human glioblastoma cell lines in vitro.Submicromolar doses of alkyl-lysophospholipids induce rapid internalization, but not activation, of epidermal growth factor receptor and concomitant MAPK/ERK activation in A431 cells.Intracellular mediators of erucylphosphocholine-induced apoptosis.In vitro and in vivo activity of miltefosine against penicillin-sensitive and -resistant Streptococcus pneumoniae strains.Surface Tension and Adsorption Studies by Drop Profile Analysis Tensiometry.A complex interplay between sphingolipid and sterol metabolism revealed by perturbations to the Leishmania metabolome caused by miltefosine.The short chain cell-permeable ceramide (C6) restores cell apoptosis and perifosine sensitivity in cultured glioblastoma cells.
P2860
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P2860
Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Alkyl-lysophospholipids as ant ...... f radiation-induced apoptosis.
@ast
Alkyl-lysophospholipids as ant ...... f radiation-induced apoptosis.
@en
type
label
Alkyl-lysophospholipids as ant ...... f radiation-induced apoptosis.
@ast
Alkyl-lysophospholipids as ant ...... f radiation-induced apoptosis.
@en
prefLabel
Alkyl-lysophospholipids as ant ...... f radiation-induced apoptosis.
@ast
Alkyl-lysophospholipids as ant ...... f radiation-induced apoptosis.
@en
P2093
P1476
Alkyl-lysophospholipids as ant ...... f radiation-induced apoptosis.
@en
P2093
van Blitterswijk WJ
P304
P356
10.1016/S0360-3016(00)01476-0
P407
P577
2001-02-01T00:00:00Z