P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.
about
Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axesEnhancement of cell membrane invaginations, vesiculation and uptake of macromolecules by protonation of the cell surface.Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp.In vitro studies in drug discovery and development: an analysis of study objectives and application of good laboratory practices (GLP).Determination of fexofenadine in Hank's balanced salt solution by high-performance liquid chromatography with ultraviolet detection: application to Caco-2 cell permeability studies.Practical aspects of transporter model systems: a case study involving SQV.The effects of intralaboratory modifications to media composition and cell source on the expression of pharmaceutically relevant transporters and metabolizing genes in the Caco-2 cell lineOpioid analgesics and P-glycoprotein efflux transporters: a potential systems-level contribution to analgesic tolerance.Drug-transporter mediated interactions between anthelminthic and antiretroviral drugs across the Caco-2 cell monolayers.Co-treatment by docetaxel and vinblastine breaks down P-glycoprotein mediated chemo-resistance.Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions.Involvement of P-glycoprotein and multidrug resistance associated protein 1 on the transepithelial transport of a mercaptoacetamide-based histone-deacetylase inhibitor in Caco-2 cells.Shear stress activation of nuclear receptor PXR in endothelial detoxification.Transporter-mediated drug-drug interactions.Alisol F 24 Acetate Enhances Chemosensitivity and Apoptosis of MCF-7/DOX Cells by Inhibiting P-Glycoprotein-Mediated Drug Efflux.Effect of lyophilized grapefruit juice on P-glycoprotein-mediated drug transport in-vitro and in-vivo.Effect of HEPES buffer on the uptake and transport of P-glycoprotein substrates and large neutral amino acids.An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine.Estimating intestinal mucosal permeation of compounds using Caco-2 cell monolayers.Lack of effect of continuous glycyrrhizin administration on the pharmacokinetics of the P-glycoprotein substrate talinolol in healthy volunteers.The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil.Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine.Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers.Modulating effect of polyethylene glycol on the intestinal transport and absorption of prednisolone, methylprednisolone and quinidine in rats by in-vitro and in-situ absorption studies.Investigation of oral bioavailability and brain distribution of the Ind(8)-Val conjugate of indinavir in rodents.Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein.Sulfasalazine transport in in-vitro, ex-vivo and in-vivo absorption models: contribution of efflux carriers and their modulation by co-administration of synthetic nature-identical fruit extracts.Effect of Passage Number and Culture Time on the Expression and Activity of Insulin-Degrading Enzyme in Caco-2 CellsLysoTracker and MitoTracker Red are transport substrates of P-glycoprotein: implications for anticancer drug design evading multidrug resistance.Effect of genistein on the activities of cytochrome P450 3A and P-glycoprotein in Chinese healthy participants.In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity.Amphiphilic Lipopeptide-Mediated Transport of Insulin and Cell Membrane Penetration Mechanism.
P2860
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P2860
P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
P-Glycoprotein (P-gp) mediated ...... ure on P-gp expression levels.
@ast
P-Glycoprotein (P-gp) mediated ...... ure on P-gp expression levels.
@en
type
label
P-Glycoprotein (P-gp) mediated ...... ure on P-gp expression levels.
@ast
P-Glycoprotein (P-gp) mediated ...... ure on P-gp expression levels.
@en
prefLabel
P-Glycoprotein (P-gp) mediated ...... ure on P-gp expression levels.
@ast
P-Glycoprotein (P-gp) mediated ...... ure on P-gp expression levels.
@en
P2093
P356
P1476
P-Glycoprotein (P-gp) mediated ...... sure on P-gp expression levels
@en
P2093
Langguth P
Niederer E
Spahn-Langguth H
Wunderli-Allenspach H
P304
P356
10.1021/JS970372E
P407
P50
P577
1998-06-01T00:00:00Z