The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnershipStructural biology and chemistry of protein arginine methyltransferasesPyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)Structure–function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein–protein interaction in C. hominis thymidylate synthase-dihydrofolate reductase (TS-DHFR)Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitorsFrom linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporterEndless Resistance. Endless Antibiotics?Meta-analysis of molecular property patterns and filtering of public datasets of antimalarial “hits” and drugsEffect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNADevelopment of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist.Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors.Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and inOpen PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns.Synthesis and Antimicrobial Activities of His(2-aryl)-Arg and Trp-His(2-aryl) Classes of Dipeptidomimetics.New trends in aminoglycosides use.Neoglycosylation and neoglycorandomization: Enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads.The biology and synthesis of α-hydroxytropolones.Antifungal Amphiphilic AminoglycosidesStructure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase.Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosisCarbohydrate antigen delivery by water soluble copolymers as potential anti-cancer vaccines.The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.Stereochemistry of Hydride Transfer by Group III Alcohol Dehydrogenases Involved in Phosphonate BiosynthesisAnti-bacterial glycosyl triazoles - Identification of an N-acetylglucosamine derivative with bacteriostatic activity against Bacillus.Synthesis and biological evaluation of panitumumab-IRDye800 conjugate as a fluorescence imaging probe for EGFR-expressing cancers.Synthesis and cytotoxicity evaluation of novel pyrido[3,4-d]pyrimidine derivatives as potential anticancer agentsCytoprotective effects of hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonists are mediated by intracellular sulfane sulfur.Optimization of the anti-cancer activity of phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching a thiourea with 1,2,3-triazoleInhibition of Ras-Effector Interaction by Cyclic Peptides.A Mast Cell Degranulation Screening Assay for the Identification of Novel Mast Cell Activating AgentsStructure-activity relationship studies of SETD8 inhibitors.Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents.Development of new N-Arylbenzamides as STAT3 Dimerization Inhibitors.Discovery of a Potent Anti-tumor Agent through Regioselective Mono-N-acylation of 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine.Synthesis, Structure-Activity Relationship, and Mechanistic Investigation of Lithocholic Acid Amphiphiles for Colon Cancer Therapy.The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.Computational ligand-based rational design: Role of conformational sampling and force fields in model development.EVALUATION OF AROMATIC 6-SUBSTITUTED THIENOPYRIMIDINES AS SCAFFOLDS AGAINST PARASITES THAT CAUSE TRYPANOSOMIASIS, LEISHMANIASIS, AND MALARIA.
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P1433
description
begutachtete wissenschaftliche Fachzeitschrift
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peer-reviewed scientific journal
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revista científica
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rivista scientifica
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vědecký časopis
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wetenschappelijk tijdschrift van Royal Society of Chemistry
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рецензований науковий журнал
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वैज्ञानिक पत्रिका
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英语期刊
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MedChemComm
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MedChemComm
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MedChemComm
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MedChemComm
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MedChemComm
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Med. Chem. Commun.
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MedChemComm
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MedChemComm
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MedChemComm
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MedChemComm
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MedChemComm
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P3181
P4616
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2011243017
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Med. Chem. Commun.
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MedChemComm
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