Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants.
about
Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2Kinetic deuterium isotope effects in cytochrome P450 oxidation reactionsA novel type of allosteric regulation: functional cooperativity in monomeric proteinsOptimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolitesFunctional expression and characterization of cytochrome P450 52A21 from Candida albicansEngineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediationPreferred binding orientations of phenacetin in CYP1A1 and CYP1A2 are associated with isoform-selective metabolism.Cytochrome P450 enzymes in the generation of commercial products.Summary of information on human CYP enzymes: human P450 metabolism data.Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis.Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis.Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1.Significant increase in phenacetin oxidation on L382V substitution in human cytochrome P450 1A2Computational and in vitro studies on the inhibitory effects of herbal compounds on human cytochrome P450 1A2.Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reductionHeterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicansN-hydroxyarylamines.Rate-limiting steps in cytochrome P450 catalysis.Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.Functional Significance of Cytochrome P450 1A2 Allelic Variants, P450 1A2*8, *15, and *16 (R456H, P42R, and R377Q).Simultaneous measurement of CYP1A2 activity, regioselectivity, and coupling: Implications for environmental sensitivity of enzyme-substrate binding.Cytochrome P450: what have we learned and what are the future issues?CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling.Life and times in biochemical toxicology.Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A6.Interactions between cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) lead to alterations in toluene disposition and P450 uncouplingThe Flavin-Containing Reductase Domain of Cytochrome P450 BM3 Acts as a Surrogate for Mammalian NADPH-P450 Reductase.Evaluation of Luminescent P450 Analysis for Directed Evolution of Human CYP4A11Carbon-carbon bond cleavage in activation of the prodrug nabumetone.The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes.High-throughput functional screening of steroid substrates with wild-type and chimeric P450 enzymes.Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors.Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.Analysis of Cytochrome P450 Conserved Sequence Motifs between Helices E and H: Prediction of Critical Motifs and Residues in Enzyme Functions.Bioactivation of Aromatic Amines by Human CYP2W1, An Orphan Cytochrome P450 Enzyme.Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression.Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps.Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions.Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase.
P2860
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P2860
Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants.
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Rate-determining steps in phen ...... P450 1A2 and selected mutants.
@ast
Rate-determining steps in phen ...... P450 1A2 and selected mutants.
@en
type
label
Rate-determining steps in phen ...... P450 1A2 and selected mutants.
@ast
Rate-determining steps in phen ...... P450 1A2 and selected mutants.
@en
prefLabel
Rate-determining steps in phen ...... P450 1A2 and selected mutants.
@ast
Rate-determining steps in phen ...... P450 1A2 and selected mutants.
@en
P2093
P356
P1433
P1476
Rate-determining steps in phen ...... P450 1A2 and selected mutants.
@en
P2093
P304
11319-11329
P356
10.1021/BI000869U
P407
P577
2000-09-01T00:00:00Z