Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome.
about
Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunitFatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency.Signaling by target of rapamycin proteins in cell growth controlCBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutationsIntrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory siteAt the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulationDAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegansCBS domains: structure, function, and pathology in human proteinsActivation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heartα-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro.A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membraneGain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscleTrypanosoma brucei AMP-activated kinase subunit homologs influence surface molecule expressionTransgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathyAMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through p38 MAPKRegulation of the muscle-specific AMP-activated protein kinase alpha2beta2gamma3 complexes by AMP and implications of the mutations in the gamma3-subunit for the AMP dependence of the enzyme.Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasisA pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway.Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy.Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.Contraction signaling to glucose transport in skeletal muscle.Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction?AMPK alterations in cardiac physiology and pathology: enemy or ally?AMP-activated protein kinase and the regulation of glucose transport.Role of AMP-activated protein kinase in healthy and diseased hearts.AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease.AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease.Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensingAssociation of AMPK subunit gene polymorphisms with growth, feed intake, and feed efficiency in meat-type chickens.Animal Models to Study AMPK.AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase.Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade.Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes.Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion.A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice.The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes.AKINbetagamma contributes to SnRK1 heterotrimeric complexes and interacts with two proteins implicated in plant pathogen resistance through its KIS/GBD sequence.
P2860
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P2860
Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Functional analysis of mutatio ...... olff-Parkinson-White syndrome.
@ast
Functional analysis of mutatio ...... olff-Parkinson-White syndrome.
@en
type
label
Functional analysis of mutatio ...... olff-Parkinson-White syndrome.
@ast
Functional analysis of mutatio ...... olff-Parkinson-White syndrome.
@en
prefLabel
Functional analysis of mutatio ...... olff-Parkinson-White syndrome.
@ast
Functional analysis of mutatio ...... olff-Parkinson-White syndrome.
@en
P356
P1476
Functional analysis of mutatio ...... Wolff-Parkinson-White syndrome
@en
P2093
Tyrone Daniel
P304
51017-51024
P356
10.1074/JBC.M207093200
P407
P577
2002-10-22T00:00:00Z