An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis. - Wikidata - awgldk - TriplyDB

An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis.

An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis.

http://www.wikidata.org/entity/Q33186139

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Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells FGF-21 as a novel metabolic regulator.Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice A novel transgenic chimaeric mouse system for the rapid functional evaluation of genes encoding secreted proteins.Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction.BMPs and their clinical potentials Potential roles of BMP9 in liver fibrosis Crystal structure of BMP-9 and functional interactions with pro-region and receptors High-throughput functional genomics identifies genes that ameliorate toxicity due to oxidative stress in neuronal HT-22 cells: GFPT2 protects cells against peroxide Bone morphogenetic protein-9 induces osteogenic differentiation of rat dental follicle stem cells in P38 and ERK1/2 MAPK dependent manner BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells Designer TGFβ superfamily ligands with diversified functionality Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes High throughput functional genomics: identification of novel genes with tumor suppressor phenotypes.TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model.Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis.Biochemical pathways analysis of microarray results: regulation of myogenesis in pigs.Retinoic acids potentiate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.Cross-talk between EGF and BMP9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells.Association of a BMP9 haplotype with ossification of the posterior longitudinal ligament (OPLL) in a Chinese population.Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.P38 and ERK1/2 MAPKs act in opposition to regulate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.Structure of the ternary signaling complex of a TGF-beta superfamily member Endoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation.Effect of Diabetes Mellitus on Adipocyte-Derived Stem Cells in Rat Functional genomics to new drug targets.The promise of genomics to identify novel therapeutic targets.Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice.Genome-scale functional profiling of the mammalian AP-1 signaling pathway.The role of myostatin and bone morphogenetic proteins in muscular disorders.The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension The Prodomain-Containing BMP9 Produced from a Stable Line Effectively Regulates the Differentiation of Mesenchymal Stem Cells.BMP signaling in mesenchymal stem cell differentiation and bone formation.BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells.BMP9 signaling in stem cell differentiation and osteogenesis.

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An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis.

http://www.wikidata.org/entity/Q33186139

description

2003 nî lūn-bûn

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2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2003年の論文

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An integrated functional genom ...... BMP-9 in glucose homeostasis.

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An integrated functional genom ...... BMP-9 in glucose homeostasis.

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An integrated functional genom ...... BMP-9 in glucose homeostasis.

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An integrated functional genom ...... BMP-9 in glucose homeostasis.

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An integrated functional genom ...... BMP-9 in glucose homeostasis.

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Nature Biotechnology

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An integrated functional genom ...... BMP-9 in glucose homeostasis.

@en

P2093

Adam C Bell

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Alokesh Duttaroy

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Baiqin Teng

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Carrie Fischer

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Cecil Chen

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Charles E Birse

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Helmut Schneider

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Indra Sanyal

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Jon Hirsch

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Krzysztof J Grzegorzewski

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Initial sequencing and analysis of the human genome

The Sequence of the Human Genome

Gene ontology: tool for the unification of biology

Growth differentiation factor-9 is required during early ovarian folliculogenesis

Profile hidden Markov models

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Bone morphogenetic protein-9. An autocrine/paracrine cytokine in the liver

Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9

New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

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294-301

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10.1038/NBT795

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3

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21

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10889361

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12598908

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