The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops.
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IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation processCrystallization of a complex between the Fab fragment of a human immunoglobulin M (IgM) rheumatoid factor (RF-AN) and the Fc fragment of human IgG4Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus developmentSomatic hypermutation introduces insertions and deletions into immunoglobulin V genesFrequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain diseaseB lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selectionOligonucleotide-assisted cleavage and ligation: a novel directional DNA cloning technology to capture cDNAs. Application in the construction of a human immune antibody phage-display libraryStability engineering of the human antibody repertoireThe human IgE repertoireGeneral strategy for the generation of human antibody variable domains with increased aggregation resistanceStructural studies of human autoantibodies. Crystal structure of a thyroid peroxidase autoantibody FabImmunoglobulin genomics in the guinea pig (Cavia porcellus)Human rheumatoid factors with restrictive specificity for rabbit immunoglobulin G: auto- and multi-reactivity, diverse VH gene segment usage and preferential usage of V lambda IIIb.A phage antibody identifying an 80-kDa membrane glycoprotein exclusively expressed on a subpopulation of activated B cells and hairy cell leukemia B cells.Isolation of anti-angiogenesis antibodies from a large combinatorial repertoire by colony filter screening.Combinatorial library cloning of human antibodies to Streptococcus pneumoniae capsular polysaccharides: variable region primary structures and evidence for somatic mutation of Fab fragments specific for capsular serotypes 6B, 14, and 23FErythropoiesis: Splenic Immunoglobulin Variable Region Genes Encoding Red Blood Cell Binding Fab Fragments in Autoimmune Hemolytic Anemia.Synthesis of Rh Fv phage-antibodies using VH and VL germline genes.Molecular mimicry between bacterial and self antigen in a patient with systemic lupus erythematosus.Phage-displayed T-cell epitope grafted into immunoglobulin heavy-chain complementarity-determining regions: an effective vaccine design tested in murine cysticercosis.Molecular analysis of HIV-1 gp120 antibody response using isotype IgM and IgG phage display libraries from a long-term non-progressor HIV-1-infected individual.Selection of recombinant antibodies specific for pathogenic Streptococcus suis by subtractive phage display.Efficient generation of respiratory syncytial virus (RSV)-neutralizing human MoAbs via human peripheral blood lymphocyte (hu-PBL)-SCID mice and scFv phage display libraries.Heterogeneity of heparan sulfates in human lung.Exegesis: a procedure to improve gene predictions and its use to find immunoglobulin superfamily proteins in the human and mouse genomes.Selection of single-chain antibodies against the VP8* subunit of rotavirus VP4 outer capsid protein and their expression in Lactobacillus casei.Minimizing the immunogenicity of antibodies for clinical application.Isolation of an IgG anti-B from a human Fab-phage display library.Recombinant human natural autoantibodies against GPIIb/IIIa inhibit binding of autoantibodies from patients with AITP.Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel.A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries.Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigensGeneration and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidney.Phage antibodies obtained by competitive selection on complement-resistant Moraxella (Branhamella) catarrhalis recognize the high-molecular-weight outer membrane protein.Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-term-nonprogressor SIV-infected macaque.Identification by phage display and characterization of two neutralizing chimpanzee monoclonal antibodies to the hepatitis E virus capsid protein.Identification of chimpanzee Fab fragments by repertoire cloning and production of a full-length humanized immunoglobulin G1 antibody that is highly efficient for neutralization of dengue type 4 virus.Functional analysis of the CXXC motif using phage antibodies that cross-react with protein disulphide-isomerase family proteins.Chimpanzee Fab fragments and a derived humanized immunoglobulin G1 antibody that efficiently cross-neutralize dengue type 1 and type 2 viruses.Synthetic antibodies as therapeutics.
P2860
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P2860
The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops.
description
1992 nî lūn-bûn
@nan
1992 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
The repertoire of human germli ...... different hypervariable loops.
@ast
The repertoire of human germli ...... different hypervariable loops.
@en
type
label
The repertoire of human germli ...... different hypervariable loops.
@ast
The repertoire of human germli ...... different hypervariable loops.
@en
prefLabel
The repertoire of human germli ...... different hypervariable loops.
@ast
The repertoire of human germli ...... different hypervariable loops.
@en
P2093
P1476
The repertoire of human germli ...... different hypervariable loops.
@en
P2093
P304
P356
10.1016/0022-2836(92)90223-7
P407
P577
1992-10-01T00:00:00Z