SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.
about
Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functionsAberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiencySenescence marker protein 30 (SMP30) expression in eukaryotic cells: existence of multiple species and membrane localizationSenescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvyPAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasisProteomic insights into an expanded cellular role for cytoplasmic lipid droplets.Proteomic analysis of fructose-induced fatty liver in hamstersLitter size manipulation in laboratory mice: an example of how proteomic analysis can uncover new mechanisms underlying the cost of reproduction.Senescence marker protein-30/superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis.Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard dietSenescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetesSenescence marker protein 30 has a cardio-protective role in doxorubicin-induced cardiac dysfunction.Senescence Marker Protein 30: Functional and Structural Insights to its Unknown Physiological Function.Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice.Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion.Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats.Regucalcin as a potential biomarker for metabolic and neuronal diseases.Molecular characterization of senescence marker protein-30 gene promoter: identification of repressor elements and functional nuclear factor binding sitesInvolvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease.Senescence-induced increases in intracellular oxidative stress and enhancement of the need for ascorbic acid in human fibroblasts.Transcriptome Analysis of Skin from SMP30/GNL Knockout Mice Reveals the Effect of Ascorbic Acid Deficiency on Skin and Hair.Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.Stem Cell Replacement Improves Expression of SMP30 in db/db Mice.Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice.Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling.Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver.Ascorbic acid prevents protein oxidation in livers of senescence marker protein-30/gluconolactonase knockout mice.Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance.Preventive Effects of Vitamin C on Diethylnitrosamine-induced Hepatotoxicity in Smp30 Knockout Mice.Regucalcin confers resistance to amyloid-β toxicity in neuronally differentiated PC12 cells.Effect of valsartan on cardiac senescence and apoptosis in a rat model of cardiotoxicity.Effect of aging on norepinephrine-related proliferative response in primary cultured periportal and perivenous hepatocytes.
P2860
Q24304361-03CAEACE-1BD3-472C-A5D4-D2AE4A109651Q27315143-C7CD0BA3-27DB-4AF2-9A7E-65F169C35D98Q28477119-664B8500-4F88-41EC-99E2-6C143C639FC1Q28578755-2441D788-B7AD-4174-9069-F0E049BD2D80Q28586356-F99D5A0D-9208-4120-98E0-D9FBF28142F7Q30492685-C1DA062A-E3E1-49FB-A68D-5368CF1D8FA3Q33353210-31E9E5FD-E36F-4E22-A549-CF4F699D34E0Q33696613-B71F48A5-5437-4315-B438-971A25253594Q33843380-3BB4F08F-3250-41E7-8005-0E1C0FCC07C8Q34766697-81C3D3BC-7EE5-4915-89CB-A2957C4145FDQ34976671-67AD1300-C223-4568-9A28-F67C34269270Q35082301-CA8AD87A-B790-4429-BD0A-D5B979AF2E08Q36119134-3FB67547-2D45-4C2B-ABBF-272D23482EF0Q36802015-06CA4917-EBB4-4296-BD81-5FA901C02B4CQ36847157-77B51BA2-3954-4438-B9B3-C741E956773AQ37198815-3495AF9B-48F1-428E-9721-107F96ADC175Q38193747-4698C972-04EA-4DAC-823D-452B26493A6BQ38529954-104A4209-9D2B-4A7B-9EBD-B8FCC54F925EQ38790566-92983CDB-A8BB-4B3E-A32D-C8D2378DA8CFQ39161534-DB0F2BA9-56CE-400A-9187-35FF05187EE3Q41487306-F11F2107-76A6-4ECB-BD10-32ACE1537F67Q42582739-CCE24B9B-3534-4026-83F8-C31B15BFE381Q43116346-80AEC057-24DE-4E05-A6FE-81C7D327F36BQ43159399-E7EC850F-E88A-4529-B6F1-AE44A1AA3FB0Q44425186-FCF2DAEA-01EB-4751-B1DB-35D9C651BE5EQ44976550-29AA6B28-93B4-4075-8B63-A47314D391E1Q45122230-BEA80FDB-50B2-47CD-9E24-FFFABD4D2219Q46134253-6DA8F942-77E9-470A-8BDA-3A1AE1667588Q47257473-0247476F-60DE-4E39-AEB2-5C7745B3B455Q52689210-7598CC98-840A-4984-AD35-BCE713C193EFQ53148765-605F4A81-9E28-4D19-BE53-EE21C949D916Q54494404-CF2D0E69-C9B7-4D68-A52F-5B36BBB654CF
P2860
SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
SMP30 deficiency in mice cause ...... er and shortens the life span.
@ast
SMP30 deficiency in mice cause ...... er and shortens the life span.
@en
type
label
SMP30 deficiency in mice cause ...... er and shortens the life span.
@ast
SMP30 deficiency in mice cause ...... er and shortens the life span.
@en
prefLabel
SMP30 deficiency in mice cause ...... er and shortens the life span.
@ast
SMP30 deficiency in mice cause ...... er and shortens the life span.
@en
P2093
P1476
SMP30 deficiency in mice cause ...... ver and shortens the life span
@en
P2093
Masumi Akita
Naoki Maruyama
Reiko Nanba
Sachiho Kubo
Setsuko Handa
Takako Ohsawa
Yoshitaka Kondo
P304
P356
10.1016/J.BBRC.2004.01.091
P407
P577
2004-03-01T00:00:00Z