Mutational biosynthesis--a tool for the generation of structural diversity in the biosynthesis of antibiotics.
about
Anticancer and immunosuppressive properties of bacterial prodigininesNatural-product sugar biosynthesis and enzymatic glycodiversification.Recent developments in antibacterial drug discovery: microbe-derived natural products--from collection to the clinic.Chemically engineered extracts as an alternative source of bioactive natural product-like compounds.Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase.Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.Vancomycin analogs: Seeking improved binding of d-Ala-d-Ala and d-Ala-d-Lac peptides by side-chain and backbone modifications.The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.Precursor-Directed Generation of Amidine Containing Ammosamide Analogs: Ammosamides E-PTargeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.Nonribosomal Peptide Synthesis-Principles and Prospects.Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant cultureFungal cyclooligomer depsipeptides: from classical biochemistry to combinatorial biosynthesis.Metabolic engineering is key to a sustainable chemical industry.Combinatorial biosynthesis in plants: a (p)review on its potential and future exploitation.Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity.Merging chemical synthesis and biosynthesis: a new chapter in the total synthesis of natural products and natural product libraries.Natural products – learning chemistry from plants.New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90.Preparation of thermocleavable conjugates based on ansamitocin and superparamagnetic nanostructured particles by a chemobiosynthetic approach.A mutasynthesis approach with a Penicillium chrysogenum ΔroqA strain yields new roquefortine D analogues.Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3.Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo.A Bio-Chemosynthetic Approach to Superparamagnetic Iron Oxide-Ansamitocin Conjugates for Use in Magnetic Drug Targeting.Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5-Lipoxygenase Inhibitors.Preparation of new alkyne-modified ansamitocins by mutasynthesis.Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations.Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents.Generation of novel pikromycin antibiotic products through mutasynthesis.Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides.Mutasynthesis of pyrrole spiroketal compound using calcimycin 3-hydroxy anthranilic acid biosynthetic mutant.Impact of epimerization domains on the intermodular transfer of enzyme-bound intermediates in nonribosomal peptide synthesis.Reprogramming the Biosynthesis of Cyclodepsipeptide Synthetases to Obtain New Enniatins and Beauvericins.De novo design and engineering of non-ribosomal peptide synthetases.In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues.Synthetic diversification of natural products: semi-synthesis and evaluation of triazole jadomycins
P2860
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P2860
Mutational biosynthesis--a tool for the generation of structural diversity in the biosynthesis of antibiotics.
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Mutational biosynthesis--a too ...... e biosynthesis of antibiotics.
@ast
Mutational biosynthesis--a too ...... e biosynthesis of antibiotics.
@en
type
label
Mutational biosynthesis--a too ...... e biosynthesis of antibiotics.
@ast
Mutational biosynthesis--a too ...... e biosynthesis of antibiotics.
@en
prefLabel
Mutational biosynthesis--a too ...... e biosynthesis of antibiotics.
@ast
Mutational biosynthesis--a too ...... e biosynthesis of antibiotics.
@en
P1476
Mutational biosynthesis--a too ...... e biosynthesis of antibiotics.
@en
P2093
P2888
P304
P356
10.1007/S00253-005-1891-8
P407
P577
2005-02-09T00:00:00Z
P6179
1040162544