The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.
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The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKsProapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathwayDisruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarineRegulatory Roles of MAPK Phosphatases in CancerSmall molecule tools for functional interrogation of protein tyrosine phosphatasesActivity of alkaloids on peptic ulcer: what's new?Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation targetDifferential Regulation of MAPK Phosphorylation in the Dorsal Hippocampus in Response to Prolonged Morphine Withdrawal-Induced Depressive-Like Symptoms in MiceBioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment.Computational methods to support high-content screening: from compound selection and data analysis to postulating target hypotheses.Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases.Conserved regulation of MAP kinase expression by PUF RNA-binding proteins.Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening.A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design.LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans.Mitogen-activated protein kinase phosphatase-1 - a potential therapeutic target in metabolic disease.Two seven-transmembrane domain MILDEW RESISTANCE LOCUS O proteins cofunction in Arabidopsis root thigmomorphogenesis.Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells.A systems approach for analysis of high content screening assay data with topic modelingMultiple model-informed open-loop control of uncertain intracellular signaling dynamicsViewing serine/threonine protein phosphatases through the eyes of drug designersScreening of Pharmacologically Active Small Molecule Compounds Identifies Antifungal Agents Against Candida BiofilmsRegulation of mitogen-activated protein kinase by protein kinase C and mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle.Histone H3 as a novel substrate for MAP kinase phosphatase-1.A fluorescence polarization binding assay to identify inhibitors of flavin-dependent monooxygenases.Molecular recognition of poly(A) targeting by protoberberine alkaloids: in vitro biophysical studies and biological perspectives.Chemical biology of histone acetyltransferase natural compounds modulators.Targeting DUSPs in glioblastomas - wielding a double-edged sword?Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease.Anticancer potential of sanguinarine for various human malignancies.Sanguinarine and Its Role in Chronic Diseases.Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype.Biophysical aspects and biological implications of the interaction of benzophenanthridine alkaloids with DNA.Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3.Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases.Spatiotemporal regulation of ERK2 by dual specificity phosphatases.Heparin treatment of vascular smooth muscle cells results in the synthesis of the dual-specificity phosphatase MKP-1.Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines
P2860
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P2860
The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The benzo[c]phenanthridine alk ...... protein kinase phosphatase-1.
@ast
The benzo[c]phenanthridine alk ...... protein kinase phosphatase-1.
@en
type
label
The benzo[c]phenanthridine alk ...... protein kinase phosphatase-1.
@ast
The benzo[c]phenanthridine alk ...... protein kinase phosphatase-1.
@en
prefLabel
The benzo[c]phenanthridine alk ...... protein kinase phosphatase-1.
@ast
The benzo[c]phenanthridine alk ...... protein kinase phosphatase-1.
@en
P2093
P2860
P356
P1476
The benzo[c]phenanthridine alk ...... protein kinase phosphatase-1.
@en
P2093
Aletheia Tamewitz
John Skoko
Kenneth A Giuliano
Rachel P Sikorski
P2860
P304
19078-19086
P356
10.1074/JBC.M501467200
P407
P577
2005-03-07T00:00:00Z