Engineering novel binding proteins from nonimmunoglobulin domains.
about
CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristicsPotent and specific inhibition of glycosidases by small artificial binding proteins (affitins)A novel, non-immunogenic Fyn SH3-derived binding protein with tumor vascular targeting propertiesModification-specific proteomics: strategies for characterization of post-translational modifications using enrichment techniquesRemodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulDNon-antibody protein-based biosensorsDrugs derived from phage display: from candidate identification to clinical practiceThe development of immunoconjugates for targeted cancer therapyConformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptorsIn vivo binding and retention of CD4-specific DARPin 57.2 in macaquesExploring the Capacity of Minimalist Protein Interfaces: Interface Energetics and Affinity Maturation to Picomolar KD of a Single-domain Antibody with a Flat ParatopeStabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formationDesign of protein function leaps by directed domain interface evolutionRedesign of a protein - peptide interaction: Characterization and applicationsStructure of a lamprey variable lymphocyte receptor in complex with a protein antigenStructural Basis for Exquisite Specificity of Affinity Clamps, Synthetic Binding Proteins Generated through Directed Domain-interface EvolutionStructural Basis of Chemokine Sequestration by a Tick Chemokine Binding Protein: The Crystal Structure of the Complex between Evasin-1 and CCL3A De Novo Protein Binding Pair By Computational Design and Directed EvolutionMolecular Basis of a Million-Fold Affinity Maturation Process in a Protein–Protein InteractionStructural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein librariesTeaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 ScaffoldDesign of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineeringStructure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target ProteinAtypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural AnalysisStructure-based optimization of designed Armadillo-repeat proteinsDesign, construction, and characterization of a second-generation DARPin library with reduced hydrophobicitySelection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep)Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G AffitinsArtificial affinity proteins as ligands of immunoglobulinsEngineering of recombinant crystallization chaperonesHigh-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domainDesired alteration of protein affinities: competitive selection of protein variants using yeast signal transduction machineryExtremophilic 50S Ribosomal RNA-Binding Protein L35Ae as a Basis for Engineering of an Alternative Protein ScaffoldAptamer-based multiplexed proteomic technology for biomarker discoveryDerivative of Extremophilic 50S Ribosomal Protein L35Ae as an Alternative Protein ScaffoldLinker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency.A novel hSH3 domain scaffold engineered to bind folded domains in CD2BP2 and HIV capsid protein.Direct detection of neuropeptide dynorphin A binding to the second extracellular loop of the κ opioid receptor using a soluble protein scaffold.Anticalins: the lipocalin family as a novel protein scaffold for the development of next-generation immunotherapies.Versatile retargeting of SH3 domain binding by modification of non-conserved loop residues.
P2860
Q21090521-2972B09A-4651-4A94-87EE-41C85C705033Q21090623-E08ADABB-430F-4CB1-B3F9-A73EF58A58ABQ24320137-9956ED76-A6C1-4679-91D3-128F68B5D1C1Q24628360-074A2617-BCB6-4FF9-9C6A-F8B8F0F65232Q24673724-AB1FE4CF-1AB1-4932-9DF2-CFA13BD9AD29Q26745879-168E521B-044B-4DB9-8F7F-06A8C2B4FD33Q27007101-0E3E3D73-5C06-437B-8E70-8E95CA9C2BABQ27021990-4709AA2F-0642-4463-9C1D-F00B88B344AEQ27318174-DDC6A6FD-C736-4287-91BD-532142E2767BQ27320871-DFDBE4CF-7CF6-4DD4-93E4-F0BB09334A8FQ27648417-ED8EFD37-EB09-41BF-99F3-AE8D1B35B473Q27650192-C4D7EF08-327F-4804-BF65-D36A42AC635AQ27650480-BF7AA93E-0F85-4AF8-BB54-5195B24638E0Q27654279-B87D88F6-B15F-41EA-876D-3DC770CA4506Q27656108-7D2D3077-A793-4EFF-B887-C332346EC3F3Q27656822-6782BD3C-FE4A-463E-926F-A065BAAC24C5Q27658814-CAE6F7F2-6086-40C8-9D70-052C7B7D3E3AQ27667402-A9E974EB-8F43-4B4E-95D4-D9B86119DCE3Q27670485-F3D1E37B-1828-437F-94E6-DB5A13B294D8Q27670954-05D8E8FD-9B22-43D6-A0E8-630DF18BF7ACQ27676439-5DCB4D34-52FE-492D-B7B1-0577866F4F8DQ27677231-1A9232C6-7474-4FED-B6FA-8921BC5C72C3Q27677469-C900D78F-1226-44DA-ADFF-4A51770B4B06Q27677883-54DC639D-B205-4E7E-BDBE-5AC92E388FB1Q27678805-B219408D-BCAC-4C49-B1E2-7BDEB0D924B7Q27679138-2E11F2A0-008D-4008-8FBF-413F5912FCC5Q27679895-192C968D-1117-450A-A0D8-992C722B2DD2Q27683766-27169E46-2D8C-4987-A4B5-0BF4DB702A5CQ28083126-7AB7F93C-DFA2-4B42-B48B-70613C4DBBA8Q28246653-3E349249-12BE-440F-8400-8EFA686166C9Q28480982-983AC5C6-8622-49F0-9083-94F089E1560FQ28543140-6975915C-4956-4E0D-A989-370A263C9A5CQ28547051-25B301E9-C9C3-467F-9C60-ABFCC0DE8DBFQ28744329-1097B9E0-628F-4C1B-9543-FB875D186BC1Q28818769-4ED089E7-C739-4AB1-9036-BA1C70EA9CB2Q30009438-029BEA50-0D1A-40C1-B96D-81FFB320AA0EQ30010007-4A1146BE-35C6-4703-98B0-2AB0654B14AAQ30153426-7AF9C211-AF2D-497B-9836-F554B8C9CFA7Q30157932-7919D708-CF74-488C-BA3F-169E09EC83C9Q30158003-3EA22217-15E3-40DB-88F0-20482DB4651E
P2860
Engineering novel binding proteins from nonimmunoglobulin domains.
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Engineering novel binding proteins from nonimmunoglobulin domains.
@ast
Engineering novel binding proteins from nonimmunoglobulin domains.
@en
type
label
Engineering novel binding proteins from nonimmunoglobulin domains.
@ast
Engineering novel binding proteins from nonimmunoglobulin domains.
@en
prefLabel
Engineering novel binding proteins from nonimmunoglobulin domains.
@ast
Engineering novel binding proteins from nonimmunoglobulin domains.
@en
P356
P1433
P1476
Engineering novel binding proteins from nonimmunoglobulin domains.
@en
P2093
H Kaspar Binz
Patrick Amstutz
P2888
P304
P356
10.1038/NBT1127
P577
2005-10-01T00:00:00Z