Comparative virtual and experimental high-throughput screening for glycogen synthase kinase-3beta inhibitors.
about
Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid DehydrogenasesComplementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain InhibitorsSystematic exploitation of multiple receptor conformations for virtual ligand screeningIspE inhibitors identified by a combination of in silico and in vitro high-throughput screeningCombining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug DiscoveryCombining cheminformatics methods and pathway analysis to identify molecules with whole-cell activity against Mycobacterium tuberculosisProtein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef proteinDesign, selection, and evaluation of a general kinase-focused library.Experimental validation of FINDSITE(comb) virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders.IKKβ inhibitor identification: a multi-filter driven novel scaffold.GSK3beta: role in therapeutic landscape and development of modulators.Structure-based virtual screening of glycogen synthase kinase 3β inhibitors: analysis of scoring functions applied to large true actives and decoy sets.Emerging topics in structure-based virtual screening.An Evaluation of Explicit Receptor Flexibility in Molecular Docking Using Molecular Dynamics and Torsion Angle Molecular DynamicsDocking and chemoinformatic screens for new ligands and targets.Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders.High-throughput and in silico screenings in drug discovery.Combining label-free cell phenotypic profiling with computational approaches for novel drug discovery.Role of computer-aided drug design in modern drug discovery.Oxazolo[4,5-b]pyridine-Based Piperazinamides as GSK-3β Inhibitors with Potential for Attenuating Inflammation and Suppression of Pro-Inflammatory Mediators.Consistent improvement of cross-docking results using binding site ensembles generated with elastic network normal modes.Virtual and experimental high-throughput screening (HTS) in search of novel inosine 5'-monophosphate dehydrogenase II (IMPDH II) inhibitors.(Z)-2-(3-Chlorobenzylidene)-3,4-dihydro-N-(2-methoxyethyl)-3-oxo-2H-benzo[b][1,4]oxazine-6-carboxamide as GSK-3β inhibitor: Identification by virtual screening and its validation in enzyme- and cell-based assay.Scoring ligand similarity in structure-based virtual screening.Changing paradigm from one target one ligand towards multi target directed ligand design for key drug targets of Alzheimer disease: An important role of Insilco methods in multi target directed ligands design.Synthesis of Novel Oxazolo[4,5-b]pyridine-2-one based 1,2,3-triazoles as Glycogen Synthase Kinase-3β Inhibitors with Anti-inflammatory Potential.Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity
P2860
Q26772046-6A8EFEE5-8A1F-4140-94B0-36D0F1CD6939Q27662173-F12BADD0-5B2A-41EB-A0CC-E1D60873519AQ28478200-EAE437AD-2B6A-40AD-84D0-E39DF92B56C4Q28483059-3B31A977-A444-4045-A05E-E7122AD81430Q28550561-4B7F0DDF-7892-489D-A868-40AA9D6C3FE3Q28709665-A5C556C2-CDB0-4E23-B79B-10771D86BB5AQ33307477-E4797A46-C82A-48F8-A87E-D9E8669B2F79Q33474002-693CB7C5-3A03-4301-82CA-66ACE4A4E9BDQ33685192-599D9F47-7719-4481-8304-F82032EA03DCQ33755579-7CA242D3-2192-4B78-8348-DE8D7CE52433Q33812730-62A82D5D-41FB-4457-B2D3-F4777B9B3A2CQ33934472-D7674247-7D9E-4BD8-8B64-5DDA730E0BE1Q34610866-60754943-116A-4A7F-986A-199F26E60EA7Q37409322-7CC99A78-F767-4142-AFAC-D88DD27AE73DQ37592631-CA0C75CC-8632-4823-A68E-5C9C0D59158FQ37657490-8602B67B-E370-4F9D-B3D2-D1888F26E197Q38088365-F8CCDA34-BDFB-46D0-B28C-90F27BC46D6DQ38366350-0BF71DAB-FED8-47C8-927A-213F0499C727Q38553677-C14DE006-C299-473F-B41F-37907A377A8DQ40185828-BF733F5A-1EB1-4C8A-AEB4-23662F47CE09Q41382543-38699158-5CAF-44CB-AF0D-FE794A58112AQ50550611-8EB8B966-7F12-4787-A5D1-4E9F2722F7E7Q51298110-7DCB6E52-AC05-40B4-8410-14465B1755BBQ51806309-9C011B58-F94A-4C4B-9B26-8D75F02D231BQ52654613-4131C9BC-6D71-48C9-BED7-28734963595CQ54219824-1F71E069-56B0-421F-BDB8-43E626E96772Q56990860-D299782C-1BDC-4C41-B778-721878603F97
P2860
Comparative virtual and experimental high-throughput screening for glycogen synthase kinase-3beta inhibitors.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Comparative virtual and experi ...... thase kinase-3beta inhibitors.
@ast
Comparative virtual and experi ...... thase kinase-3beta inhibitors.
@en
type
label
Comparative virtual and experi ...... thase kinase-3beta inhibitors.
@ast
Comparative virtual and experi ...... thase kinase-3beta inhibitors.
@en
prefLabel
Comparative virtual and experi ...... thase kinase-3beta inhibitors.
@ast
Comparative virtual and experi ...... thase kinase-3beta inhibitors.
@en
P2093
P356
P1476
Comparative virtual and experi ...... thase kinase-3beta inhibitors.
@en
P2093
Andrea Baki
György M Keseru
Györgyi I Szendrei
Tímea Polgár
P304
P356
10.1021/JM050504D
P407
P577
2005-12-01T00:00:00Z