Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains.
about
JAK2 activation by growth hormone and other cytokinesStructural reorganization of the interleukin-7 signaling complexDefining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formationMutation-introduced dimerization of receptor tyrosine kinases: from protein structure aberrations to carcinogenesis.Effects of clinically relevant MPL mutations in the transmembrane domain revealed at the atomic level through computational modeling.Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.Activation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by Friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk.Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implicationsOncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.IL-7 in human health and disease.The effect of erythropoietin on normal and neoplastic cells.Mechanism of activation of protein kinase JAK2 by the growth hormone receptor.Activation of transmembrane cell-surface receptors via a common mechanism? The "rotation model".Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias.Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulationMutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activityTransmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly.Juxtamembrane contribution to transmembrane signaling.A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.S179D prolactin: antagonistic agony!Understanding cytokine and growth factor receptor activation mechanisms.Position and role of the BK channel alpha subunit S0 helix inferred from disulfide crosslinkingIdentification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activationInteraction between the glucocorticoid and erythropoietin receptors in human erythroid cellsErythropoietin receptor response circuitsEffect of erythropoiesis-stimulating agents in acute ST-segment elevation myocardial infarction: a systematic review.Multifarious determinants of cytokine receptor signaling specificity.Targeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis.Revisiting the scissor-like mechanism of activation for the erythropoietin receptor.Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and functionCritical role of the platelet-derived growth factor receptor (PDGFR) beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein.Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch.Use of Aspirin in normalization of recombinant human erythropoietin-mediated hyper-reactivity of platelets in rats.The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling.Structural insight into the transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles.Cell biology. New tricks for an old dimer.New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.An auto-inhibitory helix in CTP:phosphocholine cytidylyltransferase hi-jacks the catalytic residue and constrains a pliable, domain-bridging helix pair.NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains.
P2860
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P2860
Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Active conformation of the ery ...... ane and transmembrane domains.
@ast
Active conformation of the ery ...... ane and transmembrane domains.
@en
type
label
Active conformation of the ery ...... ane and transmembrane domains.
@ast
Active conformation of the ery ...... ane and transmembrane domains.
@en
prefLabel
Active conformation of the ery ...... ane and transmembrane domains.
@ast
Active conformation of the ery ...... ane and transmembrane domains.
@en
P2860
P356
P1476
Active conformation of the ery ...... ane and transmembrane domains.
@en
P2093
Alec W Gross
Xiaohui Lu
P2860
P304
P356
10.1074/JBC.M512638200
P407
P577
2006-01-12T00:00:00Z