Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function.
about
Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity.Construction of a large naïve human phage-displayed Fab library through one-step cloning.Targeting of bone-derived insulin-like growth factor-II by a human neutralizing antibody suppresses the growth of prostate cancer cells in a human bone environment.A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity.Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.Engineered single human CD4 domains as potent HIV-1 inhibitors and components of vaccine immunogensHuman monoclonal antibody fragments binding to insulin-like growth factors I and II with picomolar affinity.Identification and characterization of a novel agonistic anti-DR4 human monoclonal antibody.Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulationA new bispecific antibody targeting non-overlapping epitopes on IGF2: design, in vitro characterization and pharmacokinetics in macaquesTargeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptorEarly drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials.Exceptionally potent and broadly cross-reactive, bispecific multivalent HIV-1 inhibitors based on single human CD4 and antibody domains.Expression of IGF1R in normal breast tissue and subsequent risk of breast cancerThe insulin receptor: a new target for cancer therapy.Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2.Emerging therapies for colorectal cancer.High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity.Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma.Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes.A dual-specific anti-IGF-1/IGF-2 human monoclonal antibody alone and in combination with temsirolimus for therapy of neuroblastoma.The role of IGF-1R in pediatric malignancies.Characterization of a chimeric monoclonal antibody against the insulin-like growth factor-I receptor.Implications of insulin-like growth factor-I for prostate cancer therapies.Type I insulin-like growth factor receptor signaling in hematological malignancies.Hepatic cancer stem cells and drug resistance: Relevance in targeted therapies for hepatocellular carcinoma.Targeting angiogenesis in childhood sarcomas.Antibody-based therapeutics against components of the IGF system.Targeted medical therapy of biliary tract cancer: recent advances and future perspectives.Treatment of gastrointestinal neuroendocrine tumors with inhibitors of growth factor receptors and their signaling pathways: recent advances and future perspectives.Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer.Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor.A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells.
P2860
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P2860
Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Novel human monoclonal antibod ...... signal transduction function.
@ast
Novel human monoclonal antibod ...... signal transduction function.
@en
type
label
Novel human monoclonal antibod ...... signal transduction function.
@ast
Novel human monoclonal antibod ...... signal transduction function.
@en
prefLabel
Novel human monoclonal antibod ...... signal transduction function.
@ast
Novel human monoclonal antibod ...... signal transduction function.
@en
P2093
P1476
Novel human monoclonal antibod ...... signal transduction function.
@en
P2093
Dimiter S Dimitrov
J Carl Barrett
Vidita Choudhry
Xiaodong Xiao
Zhongyu Zhu
P304
P356
10.1158/1535-7163.MCT-05-0252
P577
2006-01-01T00:00:00Z