Differential targeting of Gbetagamma-subunit signaling with small molecules. - Wikidata - awgldk - TriplyDB

Differential targeting of Gbetagamma-subunit signaling with small molecules.

Differential targeting of Gbetagamma-subunit signaling with small molecules.

http://www.wikidata.org/entity/Q33240532

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Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268 Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting Targeting G protein coupled receptor-related pathways as emerging molecular therapies Involvement of opsins in mammalian sperm thermotaxis Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions Structural determinants involved in the formation and activation of G protein betagamma dimers.Inhibition of G-protein βγ signaling enhances T cell receptor-stimulated interleukin 2 transcription in CD4+ T helper cells Endogenous opiates and behavior: 2006 Silencing of odorant receptor genes by G protein βγ signaling ensures the expression of one odorant receptor per olfactory sensory neuron.Pharmacology. Hitting the hot spots of cell signaling cascades.Turning G proteins on and off using peptide ligands.NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes.Conformational flexibility and binding interactions of the G protein βγ heterodimer.Evaluating docking methods for prediction of binding affinities of small molecules to the G protein betagamma subunits A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.Gbetagamma signaling promotes breast cancer cell migration and invasion.Development of inhibitors of heterotrimeric Gαi subunits Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.G-protein βγ subunit dimers modulate kidney repair after ischemia-reperfusion injury in rats.Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits.Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.Rational design of a selective covalent modifier of G protein βγ subunits.Mice lacking rhes show altered morphine analgesia, tolerance, and dependence.G protein modulation of CaV2 voltage-gated calcium channels A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer.Interactions of HIV and drugs of abuse: the importance of glia, neural progenitors, and host genetic factors.Molecular mechanisms of phospholipase C β3 autoinhibition.Direct-reversible binding of small molecules to G protein βγ subunits.G protein coupled receptor kinases as therapeutic targets in cardiovascular disease.G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.Corticotropin-releasing factor and urocortin I activate CREB through functionally selective Gβγ signaling in hippocampal pyramidal neurons.Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism.Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.A kinetic model for calcium dynamics in RAW 264.7 cells: 2. Knockdown response and long-term response.Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling.In silico pharmacology for drug discovery: applications to targets and beyond Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites.

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P2860

Differential targeting of Gbetagamma-subunit signaling with small molecules.

http://www.wikidata.org/entity/Q33240532

description

2006 nî lūn-bûn

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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի ապրիլին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Differential targeting of Gbetagamma-subunit signaling with small molecules.

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Differential targeting of Gbetagamma-subunit signaling with small molecules.

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type

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Differential targeting of Gbetagamma-subunit signaling with small molecules.

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Differential targeting of Gbetagamma-subunit signaling with small molecules.

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prefLabel

Differential targeting of Gbetagamma-subunit signaling with small molecules.

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Differential targeting of Gbetagamma-subunit signaling with small molecules.

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Differential targeting of Gbetagamma-subunit signaling with small molecules.

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Alan V Smrcka

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Chujun Yuan

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David M Lehmann

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Dianqing Wu

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Jean M Bidlack

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Jennifer L Mathews

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Jose L Font

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Sundeep Malik

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Tabetha M Bonacci

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10.1126/SCIENCE.1120378

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312

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16627746

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